Spatiotemporal Regulators for Insulin-Stimulated GLUT4 Vesicle Exocytosis

Journal of Diabetes Research
Xiaoxu ZhouYingke Xu

Abstract

Insulin increases glucose uptake and storage in muscle and adipose cells, which is accomplished through the mobilization of intracellular GLUT4 storage vesicles (GSVs) to the cell surface upon stimulation. Importantly, the dysfunction of insulin-regulated GLUT4 trafficking is strongly linked with peripheral insulin resistance and type 2 diabetes in human. The insulin signaling pathway, key signaling molecules involved, and precise trafficking itinerary of GSVs are largely identified. Understanding the interaction between insulin signaling molecules and key regulatory proteins that are involved in spatiotemporal regulation of GLUT4 vesicle exocytosis is of great importance to explain the pathogenesis of diabetes and may provide new potential therapeutic targets.

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Citations

Jun 16, 2019·Biology of Reproduction·Lisa M MehlmannKatie M Lowther
Jan 16, 2018·Journal of Nutritional Science and Vitaminology·Suryun JungKijin Kim
Dec 12, 2019·The Journal of Cell Biology·Walaa AlshafiePeter S McPherson
Apr 24, 2020·Microscopy Research and Technique·Luhong JinYingke Xu
Feb 23, 2019·Interventional Medicine & Applied Science·Igor Rabelo de FrançaAnderson Carlos Marçal
Sep 3, 2020·Journal of Burn Care & Research : Official Publication of the American Burn Association·Safak MertKorkut Uygun

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Methods Mentioned

BETA
GTPase
nucleotide exchange

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