Spatiotemporal Variations in Ambient Ultrafine Particles and the Incidence of Childhood Asthma.

American Journal of Respiratory and Critical Care Medicine
Eric LavigneScott Weichenthal

Abstract

Rationale: Little is known regarding the impact of ambient ultrafine particles (UFPs; <0.1 μm) on childhood asthma development. Objectives: To examine the association between prenatal and early postnatal life exposure to UFPs and development of childhood asthma. Methods: A total of 160,641 singleton live births occurring in the City of Toronto, Canada between April 1, 2006, and March 31, 2012, were identified from a birth registry. Associations between exposure to ambient air pollutants and childhood asthma incidence (up to age 6) were estimated using random effects Cox proportional hazards models, adjusting for personal- and neighborhood-level covariates. We investigated both single-pollutant and multipollutant models accounting for coexposures to particulate matter ≤2.5 μm in aerodynamic diameter (PM2.5) and NO2. Measurements and Main Results: We identified 27,062 children with incident asthma diagnosis during the follow-up. In adjusted models, second-trimester exposure to UFPs (hazard ratio per interquartile range increase, 1.09; 95% confidence interval, 1.06-1.12) was associated with asthma incidence. In models additionally adjusted for PM2.5 and nitrogen dioxide, UFPs exposure during the second trimester of pregnancy remai...Continue Reading

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Citations

Nov 15, 2019·Current Opinion in Pulmonary Medicine·Annelies BontinckGuy Joos
Nov 7, 2019·Indoor Air·Celia García-HernándezFerran Ballester
Apr 28, 2020·American Journal of Respiratory and Critical Care Medicine·Sejal SaglaniAdnan Custovic
Mar 14, 2019·American Journal of Respiratory and Critical Care Medicine·Rosalind J Wright, Brent A Coull
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Dec 31, 2020·The Journal of Allergy and Clinical Immunology·Chia-Yun HsiehBing-Fang Hwang
Mar 9, 2021·The Journal of Allergy and Clinical Immunology·Yunquan ZhangLing Zhang
May 1, 2021·International Journal of Environmental Research and Public Health·Azahara María García-SernaEva Morales
Jun 8, 2021·International Journal of Epidemiology·Malia S Q MurphyMark C Walker
Jul 27, 2021·The Journal of Allergy and Clinical Immunology·David B Peden
May 22, 2021·American Journal of Respiratory and Critical Care Medicine·Rosalind J WrightJohn L Durant
Aug 5, 2021·American Journal of Respiratory and Critical Care Medicine·Paloma I Beamer, Nathan Lothrop

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