Spatiotemporal visualization of long-term potentiation and depression in the hippocampal CA1 area

Hippocampus
T AiharaMinoru Tsukada

Abstract

Long-term potentiation (LTP) in the CA1 area of the hippocampus depends critically on the statistical characteristics of its stimulus. The ability of optical imaging to record spatial distribution has made it possible to examine systematically the effect of higher-order statistical characteristics, such as the correlation between successive pairs of inter-stimulus intervals (ISIs) on the induction of LTP. Therefore, the function of frequency (first-order) and temporal pattern (second-order) was examined using this imaging technique. To investigate the dependence of LTP on frequency, periodic stimuli with the same number of pulses were applied at different frequencies (1-10 Hz, n=200) to Schaffer commissural-collateral fibers. While stimulus frequencies from 2-10 Hz induced LTP of varying magnitudes and low-frequency stimuli (1 Hz) induced long-term depression (LTD), spatial distribution remained consistent. These results suggest that induction frequency has a greater effect on the magnitude of LTP than on its spatial distribution. By employing nonperiodic stimuli at the same mean frequency (2 Hz), the effect of varying the temporal structure of a stimulus was also investigated. As the correlation of successive ISIs was increase...Continue Reading

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Citations

Nov 27, 2008·Cognitive Neurodynamics·Kimitaka KanekiMinoru Tsukada
Jul 29, 2006·The Journal of Physiology·Payne Y Chang, Meyer B Jackson
Aug 12, 2006·Neuropharmacology·Sven BerberichGeorg Köhr
Jul 12, 2018·Journal of Neural Transmission·Udo BonnetMartin Wiemann
Dec 6, 2005·The European Journal of Neuroscience·Paolo BonifaziVincent Torre
Sep 13, 2013·Journal of Neurophysiology·Meyer B Jackson

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