Special article: gait measures indicate underlying focal gray matter atrophy in the brain of older adults.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Caterina RosanoAnne B Newman

Abstract

Our objective was to identify the spatial distribution of focal atrophy within mobility-related brain regions in relationship with quantitative gait characteristics. Gray matter volume was obtained from 220 older adults (78.0 years old, 63% women, 77% white) for brain regions of five domains: motor (motor, sensorimotor and supplementary areas, basal ganglia, cerebellum), visuospatial attention (inferior and superior posterior parietal lobules), cognitive processing speed/executive control function (dorsolateral prefrontal cortex), memory (hippocampus), and motor imagery (parahippocampus, posterior cingulated cortex) domains. Spatial (step width, step length) and temporal (double support time) gait characteristics were measured using the GaitMat II instrumented walking surface. Multivariable linear regression models were adjusted for demographics, total brain volume, and peripheral (body mass index, ankle-arm index, arthritis, vibratory sensation) and central (markers of diffuse brain structural abnormalities and of brain function) risk factors for gait impairment. Shorter steps and longer double support times were associated with smaller sensorimotor regions and also with smaller frontoparietal regions within the motor, visuosp...Continue Reading

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Citations

Dec 1, 2012·Journal of Neural Transmission·C AnnweilerUNKNOWN WALK Team-Working group Angers-London for Knowledge
Mar 23, 2012·Age and Ageing·Jennifer C DavisTeresa Liu-Ambrose
Dec 17, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Takehiko DoiTakao Suzuki
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