PMID: 6972986Mar 1, 1981Paper

Special features of the priming process for a secretory IgA response. B cell priming with cholera toxin

The Journal of Experimental Medicine
J A Fuhrman, J J Cebra

Abstract

Administration of cholera toxin/toxoid by either intraduodenal or parenteral routes increases the frequency of antigen-sensitive B cells in Peyer's patches (PP) and in distant lymphoid tissues greater than 50-fold. The special feature of mucosal priming with toxin is its unique effectiveness at generating secondary B cells, whose progeny express IgA exclusively, and such cells appear in highest frequency in PP and in appreciable numbers in spleen. Thus, this deliberate intraduodenal immunization seems to mimic the natural priming process induced by enteric bacterial colonization, which we have postulated to account for the high frequencies of IgA-committed cells specific for bacterial determinants in the PP of conventionally reared mice. furthermore, as a result of intraduodenal immunization, antigen-specific memory B cells are disseminated to sites distant form that of antigen application, including the lymphoid follicles associated with the respiratory mucosa. Direct antigenic stimulation of cells in the PP therefore results in effective cross-priming among mucosal and systemic sites through division, differentiation, and disemination of antigen-sensitive secondary B cells.

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Citations

Sep 1, 1983·Molecular Immunology·E R Clough, J J Cebra
Feb 1, 1983·The Journal of Experimental Medicine·J H EldridgeJ R McGhee
Feb 1, 1987·The Journal of Experimental Medicine·L W Duran, E S Metcalf
May 1, 1993·Acta Oto-laryngologica·G CortesinaC Ruffino
Jan 1, 1985·Scandinavian Journal of Gastroenterology. Supplement·P Brandtzaeg
Dec 1, 1984·Experimental Parasitology·P D MurrayH C Passmore
Feb 1, 1983·Scandinavian Journal of Immunology·D A RivierM F Kagnoff
Jun 30, 1983·Annals of the New York Academy of Sciences·J E ButlerM T Suelzer
Jun 30, 1983·Annals of the New York Academy of Sciences·P C MontgomeryJ H Rockey
Jun 30, 1983·Annals of the New York Academy of Sciences·J J CebraR D Shahin
Nov 1, 1983·The Journal of Allergy and Clinical Immunology·M E Pichichero, R A Insel
Jun 1, 1989·European Journal of Immunology·S SchoenbeckM F Kagnoff
Aug 1, 1986·European Journal of Immunology·P M Wathen, D D Manning
Dec 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mirjam SchenkChristoph Mueller

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