Special Issue: Gene Conversion in Duplicated Genes

Genes
Hideki Innan

Abstract

Gene conversion is an outcome of recombination, causing non-reciprocal transfer of a DNA fragment. Several decades later than the discovery of crossing over, gene conversion was first recognized in fungi when non-Mendelian allelic distortion was observed. Gene conversion occurs when a double-strand break is repaired by using homologous sequences in the genome. In meiosis, there is a strong preference to use the orthologous region (allelic gene conversion), which causes non-Mendelian allelic distortion, but paralogous or duplicated regions can also be used for the repair (inter-locus gene conversion, also referred to as non-allelic and ectopic gene conversion). The focus of this special issue is the latter, interlocus gene conversion; the rate is lower than allelic gene conversion but it has more impact on phenotype because more drastic changes in DNA sequence are involved. [...].

References

Nov 29, 2010·Genes·P J Hastings
Jan 1, 2010·Genes·Jian-Min ChenDavid N Cooper
Jan 1, 2011·Genes·Kohei Kurosawa, Kunihiro Ohta
Jan 1, 2011·Genes·J Roman Arguello, Tim Connallon
Jan 1, 2011·Genes·Jeffrey A Fawcett, Hideki Innan
Jan 1, 2011·Genes·Sayaka P MansaiHideki Innan

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Citations

Apr 5, 2013·PloS One·Kershney NaidooBrenda D Wingfield

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