Special populations: the management of seizures in HIV-positive patients

Current Neurology and Neuroscience Reports
Paul MullinRohit Bakshi

Abstract

An increasing percentage of patients with new-onset seizures are HIV positive. The evaluation and management is distinctly different from managing the non-HIV-infected patient. Clinicians must be familiar with comorbid infectious etiologies and the relative value of electroencephalogram, imaging, and serum and cerebrospinal fluid laboratory tests. Traditional antiepileptic drug (AED) therapies are contraindicated and may lead to increased HIV viral replication through either directed cellular mechanisms or interference with antiretroviral therapies. Newer AEDs have pharmacokinetic properties that make them reasonable choices, although none have been specifically studied for efficacy or safety in HIV. Lastly, optimal choice of an AED should reflect commonly encountered neurologic and psychiatric comorbidities.

References

Aug 1, 1992·Acta Neurologica Scandinavica·A P SempereJ A Tejerina
Nov 27, 1991·JAMA : the Journal of the American Medical Association·E M SloandG J Nemo
Jul 1, 1995·The American Journal of Medicine·A MoulignierJ B Thiebaut
Jul 1, 1995·Journal of Computer Assisted Tomography·K VillringerM Schwaiger
Oct 1, 1996·Neuropathology and Applied Neurobiology·F ChrétienF Gray
Jan 20, 1997·AIDS Research and Human Retroviruses·M WitvrouwE De Clercq
Oct 1, 1998·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·G R Pesola, R E Westfal
Dec 22, 1998·Epilepsia·A PrimaveraL Cocito
Jan 8, 1999·Journal of the Neurological Sciences·S FerrariN Rizzuto
Jan 29, 1999·Archives of Neurology·F BartolomeiJ L Gastaut
Apr 18, 2000·Epilepsia·W R Garnett
Apr 20, 2000·The Annals of Pharmacotherapy·P W HugenY A Hekster
Jul 25, 2000·Pharmacotherapy·Y KatoS R Kayser
Dec 21, 2000·Current Psychiatry Reports·D S Janowsky
Apr 11, 2001·Journal of the Peripheral Nervous System : JPNS·C A PardoJ W Griffin
Aug 18, 2001·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·I La SpinaF Suter
Aug 30, 2002·Epilepsia·Martin J BrodieUNKNOWN Gabapentin Study Group 945-212
Mar 4, 2003·The American Journal of Psychiatry·Benedetto VitielloMartin F Shapiro
Apr 16, 2003·Epilepsy & Behavior : E&B·Ilo E LeppikThaddeus Walczak
Aug 27, 2003·Southern Medical Journal·Kristina M KlineKaren F Malnar
Feb 10, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Rohit Bakshi

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Citations

Mar 30, 2006·Current Treatment Options in Neurology·Cheryl A Jay
Sep 1, 2009·Journal of Clinical Pharmacology·Matthijs van LuinDavid M Burger
Aug 17, 2005·Epilepsy & Behavior : E&B·Steven KarceskiDaniel Carpenter
Jul 10, 2007·Seizure : the Journal of the British Epilepsy Association·C KellinghausI W Husstedt
Oct 19, 2010·Seizure : the Journal of the British Epilepsy Association·Yaseen YacoobRaveen Parboosing
Oct 22, 2005·Acta Neurologica Scandinavica. Supplementum·A I Bhigjee
Dec 7, 2007·Farmacia hospitalaria : órgano oficial de expresión científica de la Sociedad Española de Farmacia Hospitalaria·P AmarilesM J Faus

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