Specialized sperm function tests in varicocele and the future of andrology laboratory

Asian Journal of Andrology
Ahmad MajzoubAshok Agarwal

Abstract

Varicocele is a common medical condition entangled with many controversies. Though it is highly prevalent in men with infertility, still it marks its presence in males who do have normal fertility. Determining which patients are negatively affected by varicocele would enable clinicians to better select those men who benefitted the most from surgery. Since conventional semen analysis has been limited in its ability to evaluate the negative effects of varicocele on fertility, a multitude of specialized laboratory tests have emerged. In this review, we examine the role and significance of specialized sperm function tests with regards to varicocele. Among the various tests, analysis of sperm DNA fragmentation and measurements of oxidative stress markers provide an independent measure of fertility in men with varicocele. These diagnostic modalities have both diagnostic and prognostic information complementary to, but distinct from conventional sperm parameters. Test results can guide management and aid in monitoring intervention outcomes. Proteomics, metabolomics, and genomics are areas; though still developing, holding promise to revolutionize our understanding of reproductive physiology, including varicocele.

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Citations

Jan 20, 2016·Asian Journal of Andrology·Ashok Agarwal, Sandro C Esteves
Jan 20, 2016·Asian Journal of Andrology·Sandro C Esteves, Ashok Agarwal
Jul 18, 2016·Journal of Assisted Reproduction and Genetics·Sandro C Esteves
Sep 28, 2016·Reproduction in Domestic Animals = Zuchthygiene·W NiżańskiS Prochowska
Apr 17, 2019·Panminerva Medica·Ahmad MajzoubSandro C Esteves
May 2, 2018·Arab Journal of Urology·Chak-Lam Cho, Ashok Agarwal
Nov 22, 2019·The World Journal of Men's Health·Christopher DouglasAshok Agarwal
Jun 20, 2020·Andrologia·Manesh Kumar Panner SelvamRalf Henkel
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Sep 30, 2020·Postgraduate Medicine·David Miller, Josip Vukina
Mar 16, 2018·International Urology and Nephrology·Matheus Roque, Sandro C Esteves
Jul 4, 2018·Nature Reviews. Urology·Sandro C EstevesPeter Humaidan
May 27, 2020·Andrologia·Manesh Kumar Panner SelvamRalf Henkel
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Aug 21, 2020·Andrologia·Mahshid HosseiniMohammad Hossein Nasr-Esfahani
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Aug 28, 2021·Journal of Clinical Medicine·Ana Paula SousaJoão Ramalho-Santos
Jul 12, 2017·Gynécologie, Obstétrique, Fertilité & Sénologie·A DumontG Robin

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