PMID: 18425264Apr 22, 2008Paper

Speciation of antimony (III) and antimony (V) using hydride generation for meglumine antimoniate pharmaceutical formulations quality control

Memórias do Instituto Oswaldo Cruz
Lúcio Mendes CabralTerezsa Cristina Dos Santos

Abstract

The pentavalent antimonies, mainly the meglumine antimoniate, are recommends as first-choice medicines for leishmaniasis therapy. In this work we described the development of formulations of meglumine antimoniate injectable medication, as well as the analytical methodology used in the selective determination of Sb(III) and Sb(Total) by hydride generation - inductively coupled plasma atomic emission spectrometry (HG-ICP-AES) and ICP-AES, respectively. On that purpose the analytical methodology was developed focusing on the HG-ICP-AES technique. The formulations using propylene glycol/water as vehicles in a 20:80 proportion were more appropriate for subsequent use in industrial scale. These formulations also showed a lower variation on Sb(III) percentage, no need of buffer solution to stabilize the formulation and no influence of the autoclaving in the quality of the product. The results of the development of the analytical methodology point out the proposed method as an efficient alternative for the determination of Sb(III) in the presence of large quantities of Sb(V) in injectable solutions of meglumine antimoniate, in a selective, linear, accurate and precise manner. In addition, the method showed a low limit of quantification...Continue Reading

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Citations

Apr 7, 2012·Analytical and Bioanalytical Chemistry·Björn Meermann, Michael Sperling
Mar 9, 2010·Journal of Pharmaceutical and Biomedical Analysis·L Łukaszczyk, W Zyrnicki
May 9, 2009·Journal of Pharmaceutical and Biomedical Analysis·Vivian Silva SantosCésar Ricardo Teixeira Tarley
Mar 30, 2016·Analytical and Bioanalytical Chemistry·Juliano S BarinErico M M Flores
Jan 7, 2020·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Iván Moreno-AndradeReyes Sierra-Alvarez
Dec 28, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Betânia Mara AlvarengaJosé Dias Corrêa Junior

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