Species- and Tissue-Specific Avian Chronic Toxicity Values for Perfluorooctane Sulfonate (PFOS) and a Binary Mixture of PFOS and Perfluorohexane Sulfonate.

Environmental Toxicology and Chemistry
Nicole M DennisTodd A Anderson

Abstract

To further characterize avian toxicity to environmental levels of select per- and poly-fluoroalkyl substances (PFAS), we established species- and tissue-specific PFAS chronic toxicity values (CTVs) associated with a lowest-observable-adverse effect level (LOAEL) threshold previously established for northern bobwhite quail (Colinus virginianus) chronically orally exposed via drinking water to either perfluorooctane sulfonate (PFOS) or a simple PFAS mixture. Aided by advances in analytical techniques, the novel avian oral PFAS CTVs reported in the present study are lower than the previously reported toxicity reference values (TRVs) estimated for birds chronically exposed via feed. Thus, current avian PFOS TRVs may not be fully protective of wild avian populations at PFAS-impacted sites. Also, likely due to differences in bioavailability, bioaccessibility, and toxicokinetics among individual PFAS between oral exposure types, we found higher bioaccumulation factors in all assessed tissues from birds exposed via water versus feed. Thus, we propose that future characterization of chemical toxicity due to ingestion exposure initially include a full examination of all probable sources of oral exposure for the most accurate derivation o...Continue Reading

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Mar 8, 2020·International Journal of Environmental Research and Public Health·Alexis M TemkinLisa M Kamendulis

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Citations

Mar 23, 2021·Integrated Environmental Assessment and Management·Christopher J McCarthyElizabeth T Middleton
Apr 10, 2021·Environmental Toxicology and Chemistry·Christopher J McCarthyChristopher J Salice
Jul 9, 2021·Environmental Toxicology and Chemistry·Allison M NarizzanoMichael J Quinn

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