PMID: 3383840Jan 1, 1988Paper

Species and sex differences in genotoxicity of heterocyclic amine pyrolysis and cooking products in the hepatocyte primary culture/DNA repair test using rat, mouse, and hamster hepatocytes

Environmental and Molecular Mutagenesis
N YoshimiG M Williams

Abstract

Eleven mutagenic heterocyclic amines, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]-indole (Trp-P-1), 3-amino-1-methyl-5H-pyrido[4,3]indole (Trp-P-2), 2-amino-6-methyl-dipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1), 2-aminodipyrido[1,2-a:3',2'-d]imidazole (Glu-P-2), 2-amino-9H-pyrido[2,3-b]indole (A alpha C), 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeA alpha C), 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ), 2-amino-3,8-dimethylimidazo [4,5-f]quinoline (MeIQX), 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline (4,8-diMeIQX), and 2-amino-3,7,8-trimethylimidazo[4,5-f]quinoxaline (7,8-diMeIQX), were studied for genotoxicity in the hepatocyte/DNA repair test employing hepatocytes of male rats, male and female mice, and male hamsters. In these four assay systems, all compounds elicited DNA repair in at least three systems, except Trp-P-2, which was uniformly inactive. However, there were several significant differences in the responses of different systems. Rat and hamster hepatocytes responded to nine of the ten genotoxic compounds with the exception of Glu-P-2. Male and female mouse hepatocytes responded to Glu-P-2, whereas female, but not male, mouse hepatocytes responded to MeIQX and 4,8-di...Continue Reading

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Citations

Mar 1, 1991·Mutation Research·H U Aeschbacher, R J Turesky
Nov 1, 1995·Critical Reviews in Oncology/hematology·A M LynchA R Boobis
Jul 23, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M J RamseyJ D Tucker
Jul 23, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J A BeamandB G Lake
Sep 16, 1998·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·K I SkogM I Jägerstad
Jun 6, 2000·Mutation Research·T M de Kok, J M van Maanen
Feb 1, 1994·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·O S SohnJ H Weisburger
Dec 25, 2004·Cancer Letters·Takeshi IidakaMasae Tatematsu
Jun 30, 2000·Carcinogenesis·R S KingF F Kadlubar
Nov 21, 2019·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Xiaoqing GuoNan Mei

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