PMID: 3768685Sep 24, 1986Paper

Species and structural specificity of the lipopigment accumulation and neuronal destruction induced by N-(2-guanidinoethyl)-4-methyl-1,2,5,6-tetrahydropyridine (guanacline)

Brain Research
E M JohnsonP T Manning

Abstract

Guanacline, a guanidinium adrenergic neuron blocking agent similar to guanethidine, was studied clinically and experimentally during the late 1960s. Like guanethidine, it has been reported to produce sympathetic neuronal destruction in rats. Unlike guanethidine, it has been reported to produce irreversible sympathetic deficits in man and to produce fluorescent lipopigment in rat sympathetic neurons. Guanacline and its derivative in which the double bond of the tetrahydropyridine ring is reduced (saturated analog of guanacline, SAG) were prepared. Several species were treated chronically with varying doses of guanethidine, guanacline or SAG; the superior cervical ganglia were examined light microscopically for neuronal destruction and for osmiophilic fluorescent lipopigment accumulation. All 3 drugs produced rapid neuronal destruction in rats accompanied by massive small-cell infiltration. In striking contrast, treatment for many weeks with doses up to 100 mg/kg/day produced no small-cell infiltration or apparent neuronal destruction in mice or guinea pigs. The neuronal destruction produced by guanacline and SAG in the rat, like that caused by guanethidine, was prevented by immunosuppression or gamma-irradiation, indicating that...Continue Reading

References

May 1, 1974·European Journal of Pharmacology·J F Gerkens
Mar 1, 1960·Proceedings of the National Academy of Sciences of the United States of America·R Levi-Montalcini, B Booker

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Citations

Feb 17, 1997·Journal of the Autonomic Nervous System·M J Picklo
Nov 25, 2011·PLoS Pathogens·Grégoire ChevalierDaniel Gonzalez-Dunia
Jan 1, 1987·Annals of Neurology·M A PalmatierE M Johnson
Jul 1, 1989·The British Journal of Psychiatry : the Journal of Mental Science·J H Dowson
Jul 2, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nico MelzerHeinz Wiendl

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