Species and tissue specificities of I-compounds as contrasted with carcinogen adducts in liver, kidney and skin DNA of Sprague-Dawley rats, ICR mice and Syrian hamsters

Carcinogenesis
D H LiK Randerath

Abstract

I-compounds are age-related bulky DNA modifications that are detected in untreated animals by 32P-postlabeling. To characterize their properties, I-compounds were compared with carcinogen-DNA adducts in liver, kidney and skin of three rodent species. Weanling female Sprague-Dawley rats, ICR mice and Syrian hamsters were fed Teklad LM485 chow diet for 3 months and raised concurrently and strictly under the same environmental conditions. Animals of each species were treated topically with 24 mumol/kg dibenz[a,j]acridine per day for 3 days, then by gavage once with a mixture of safrole and 7,12-dimethylbenz[a]anthracene (60 and 80 mumol/kg respectively), or with one of the individual carcinogens. Liver, kidney and skin DNA from carcinogen-exposed (24 h after treatment) and unexposed animals was analyzed by the monophosphate version of the 32P-postlabeling assay. While each of the three carcinogens produced qualitatively identical major adduct patterns in all samples examined, I-compounds in untreated animals showed distinct species- and tissue-dependent profiles. Rats displayed the highest I-compound levels but the lowest adduct levels in both liver and kidney among the three species. These findings demonstrate fundamental differe...Continue Reading

Citations

Apr 11, 2003·The Science of the Total Environment·S BinetM Castegnaro
Jan 1, 1994·Drug Metabolism Reviews·K Randerath, E Randerath
Dec 14, 2004·Angewandte Chemie·Wolfgang SchraderWerner Joppek
Dec 12, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Gary M WilliamsJian-Dong Duan
Feb 26, 2000·Carcinogenesis·L J Marnett

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