Species C Rotaviruses in Children with Diarrhea in India, 2010-2013: A Potentially Neglected Cause of Acute Gastroenteritis

Pathogens
Sudipta BhatNobumichi Kobayashi

Abstract

All over the world, children and adults are severely affected by acute gastroenteritis, caused by one of the emerging enteric pathogens, rotavirus C (RVC). At present, no extensive surveillance program is running for RVC in India, and its prevalence is largely unknown except cases of local outbreaks. Here, we intended to detect the presence of RVC in diarrheic children visiting or admitted to hospitals in Haldwani (state of Uttarakhand, India), a city located in the foothills of the Himalayas. During 2010-2013, we screened 119 samples for RVC by an RVC VP6 gene-specific RT-PCR. Of these, 38 (31.93%) were found positive, which is higher than the incidence rates reported so far from India. The phylogenetic analysis of the derived nucleotide sequences from one of the human RVC (HuRVC) isolates, designated as HuRVC/H28/2013/India, showed that the study isolate belongs to genotype I2, P2 and E2 for RVC structural genes 6 and 4 (VP6, and VP4) and non-structural gene 4 (NSP4), respectively. Furthermore, the VP6 gene of HuRVC/H28/2013/India shows the highest similarity to a recently-reported human-like porcine RVC (PoRVC/ASM140/2013/India, KT932963) from India suggesting zoonotic transmission. We also report a full-length NSP4 gene seq...Continue Reading

References

Sep 1, 1989·The Journal of Infectious Diseases·M E PeñarandaR I Glass
Nov 1, 1988·Journal of Clinical Microbiology·D W BrownV I Mathan
Oct 1, 1982·Journal of Clinical Microbiology·S M RodgerI H Holmes
Jul 1, 1994·Journal of Medical Virology·N B RasoolK Y Green
Jan 1, 1993·Microbiology and Immunology·I OishiY Minekawa
Jan 27, 1999·Bioinformatics·D Posada, K A Crandall
Aug 19, 2000·The Journal of Infectious Diseases·M NilssonL Svensson
Jan 31, 2003·Archives of Virology·A Sánchez-FauquierB Jiang
Aug 7, 2004·The Journal of Veterinary Medical Science·Takahiro MawatariHiroshi Tsunemitsu
Oct 21, 2004·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Miren Iturriza-GómaraJim Gray
Sep 8, 2005·Journal of Clinical Microbiology·Mustafizur RahmanTasnim Azim
Sep 20, 2005·East African Medical Journal·J M MwendaA D Steele
Apr 9, 2008·Applied and Environmental Microbiology·Edina MelegGyörgy Szucs
Jul 8, 2008·Archives of Virology·Jelle MatthijnssensMarc Van Ranst
Jul 24, 2008·Journal of Medical Virology·Yvone B GabbayBaoming Jiang
Sep 3, 2009·Epidemiology and Infection·I MukhopadhyaG Kang
Oct 10, 2009·Virology Journal·Stacy R FinkbeinerDavid Wang
May 25, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S MoonB Jiang
Nov 5, 2010·The Journal of General Virology·Dai YamamotoNobumichi Kobayashi
Mar 21, 2012·Archives of Virology·Jelle MatthijnssensReimar Johne
Oct 12, 2012·The Journal of General Virology·Junichi SomaTohru Suzuki
Dec 1, 2011·Indian Journal of Virology : an Official Organ of Indian Virological Society·Y P S MalikG Prasad
May 7, 2013·Veterinary Microbiology·Hajnalka PappKrisztián Bányai
Oct 18, 2013·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Jun 15, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Tohru SuzukiHiroshi Tsunemitsu
Jul 13, 2014·Virus Research·Ulrich Desselberger
Oct 4, 2014·Clinical Microbiology Reviews·Albert BoschSusana Guix
Dec 17, 2014·Molecular Genetics and Genomics : MGG·Adriana Luchs, Maria do Carmo Sampaio Tavares Timenetsky
Jan 17, 2015·Veterinary Microbiology·Young-Ju JeongKyoung-Oh Cho
Mar 27, 2015·Emerging Infectious Diseases·Eszter Mihalov-KovácsKrisztián Bányai
Apr 29, 2015·The Veterinary Quarterly·Kuldeep DhamaRaj Kumar Singh
Aug 25, 2015·The Journal of General Virology·Szilvia MartonKrisztián Bányai
Jan 17, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Elena ZhirakovskaiaNina Tikunova
Feb 18, 2016·Gastroenterology Research and Practice·Anahita Sanaei DashtiAbdollah Karimi
Apr 2, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Yashpal Singh MalikRaj Kumar Singh

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Citations

Mar 21, 2019·Voprosy virusologii·K M KhametovaT V Grebennikova
May 18, 2020·Zoonoses and Public Health·Fábio Burack CostaNorma Santos
Mar 9, 2019·Zoonoses and Public Health·Nídia S TrovãoDouglas G Marthaler

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Datasets Mentioned

BETA
MG553198
MG553199
MG553200
AY786570

Methods Mentioned

BETA
genotyping
Assay
PCR
electrophoresis
Glycosylation

Software Mentioned

NetNGlyc
MEGA
FindModel
MegAlign
DNASTAR
Clustal V

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