Species characterization and minimum inhibitory concentration patterns of Brachyspira species isolates from swine with clinical disease

Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
Kristin A ClothierKent Schwartz

Abstract

Typhlocolitis and dysentery due to Brachyspira hyodysenteriae infection represent an economically important disease syndrome in growing pigs. Largely disappearing from U.S. swine herds in the late 1990 s and early 2000s, Brachyspira-associated disease and bacterial isolation from swine with clinical disease has increased in the last several years, and non-B. hyodysenteriae isolates are commonly identified. Antimicrobial resistance has been demonstrated in Brachyspira spp. isolates from Europe and Asia, and may be the reason for the resurgence in U.S. herds. Seventy-nine clinical isolates identified at the Iowa State University Veterinary Diagnostic Lab were tested with multiple polymerase chain reaction assays to establish species identity, and evaluated for minimum inhibitory concentrations (MICs) using an agar dilution method against lincomycin, gentamicin, valnemulin, tiamulin, salinomycin, and carbadox. Only 38.0% of isolates could be confirmed as the known pathogens B. hyodysenteriae (30.4%) or Brachyspira pilosicoli (7.6%). Twenty of the 79 isolates (25.3%) were identified as Brachyspira murdochii, and 13.9% could not be identified to species. The MIC values were consistently high against lincomycin and moderately high ag...Continue Reading

References

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Citations

May 6, 2014·The Journal of Antimicrobial Chemotherapy·Engeline van DuijkerenKarolina Törneke
Apr 2, 2014·The Veterinary Journal·Satu PyöräläKarolina Törneke
Mar 12, 2016·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Nandita S Mirajkar, Connie J Gebhart
Jun 12, 2016·Veterinary Pathology·E R Burrough
Mar 23, 2017·Canadian Journal of Microbiology·D G R S Kulathunga, J E Rubin
Dec 20, 2014·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Bailey L WilbertsEric R Burrough
Sep 8, 2012·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Eric R BurroughJ Glenn Songer
Aug 24, 2012·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Yogesh ChanderConnie J Gebhart
Sep 25, 2016·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Luis M Aller-MoránAna Carvajal
Jun 3, 2016·Journal of Clinical Microbiology·Nandita S MirajkarConnie J Gebhart
Apr 15, 2018·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Jih-Ching YehHung-Chih Kuo
Jan 24, 2020·Microbiology Spectrum·Marie Archambault, Joseph E Rubin

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Methods Mentioned

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