Species comparison of steroid UDP-glucuronyl transferase: correlation to TCDD sensitivity

Toxicology Letters
T H UmbreitM A Gallo

Abstract

Estradiol glucuronidation via steroid UDP-glucuronyl transferase (sUDPGT) was examined in 2,3,7,8-te trachlorodibenzo-p-dioxin (TCDD) sensitive and resistant species and strains. Steroid UDPGT was not induced by treatment with TCDD or estradiol. The most sensitive species to TCDD lethality, the guinea pig, had relatively high steroid UDPGT activity, while the hamster, the most resistant species, and rats had low levels of activity; no differences in sUDPGT activities were observed between mouse or rat strains differing in susceptibility to TCDD intoxication. These results suggest a role for differences in steroid physiology in the determination of species susceptibility to TCDD, but also demonstrate that other factors are involved.

References

Aug 1, 1977·Journal of Steroid Biochemistry·G W Lucier, O S McDaniel
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May 1, 1987·Endocrine Reviews·J A GustafssonA Cintra
Oct 1, 1988·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·J R GorskiK Rozman
Jan 1, 1988·Toxicology Letters·T H UmbreitM A Gallo
Feb 1, 1987·Pharmacology & Toxicology·R PohjanvirtaK Rozman
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Sep 1, 1973·Environmental Health Perspectives·B A SchwetzC G Gerbig
Jun 30, 1981·Toxicology and Applied Pharmacology·J M HenckK S Rao

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