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Species differences in metabolism of tiaramide hydrochloride, a new anti-inflammatory agent

Xenobiotica; the Fate of Foreign Compounds in Biological Systems

Aug 1, 1977

H NoguchiR Kato

PMID: 407731

Abstract

1. Urinary excretion of the radioactivity in 24 h after oral administration of [14C]tiaramide hydrochloride was 67% of the dose in mice, 59% in rats, 41% in dogs and 74% in monkeys. 2. The serum half-lives of tiaramide after intravenous administration were approximately 0-2 h in mice, 0...read more

Mentioned in this Paper

Metabolic Process, Cellular
Piperazine
Desethanol tiaramide
Lung
Monohydroxyethylpiperazine
Anti-Inflammatory Agents
Tissue Specificity
Brain
Serum Proteins
Plasma Protein Assay
Paper Details
References
  • References13
  • Citations6
12

Species differences in metabolism of tiaramide hydrochloride, a new anti-inflammatory agent

Xenobiotica; the Fate of Foreign Compounds in Biological Systems

Aug 1, 1977

H NoguchiR Kato

PMID: 407731

DOI:

Abstract

1. Urinary excretion of the radioactivity in 24 h after oral administration of [14C]tiaramide hydrochloride was 67% of the dose in mice, 59% in rats, 41% in dogs and 74% in monkeys. 2. The serum half-lives of tiaramide after intravenous administration were approximately 0-2 h in mice, 0...read more

Mentioned in this Paper

Metabolic Process, Cellular
Piperazine
Desethanol tiaramide
Lung
Monohydroxyethylpiperazine
Anti-Inflammatory Agents
Tissue Specificity
Brain
Serum Proteins
Plasma Protein Assay

Related Papers

Paper Details
References
  • References13
  • Citations6
12
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