PMID: 6168824May 1, 1981Paper

Species differences in renal vascular effects of dipyridamole and in the potentiation of adenosine action by dipyridamole

Journal of Cardiovascular Pharmacology
K SakaiK Haruta

Abstract

The effects of dipyridamole and adenosine on the renal vasculature and on the enhancement by dipyridamole of the action of adenosine were studied in pigs, dogs, rabbits, and rats. Intravenous adenosine in doses of 10-300 micrograms/kg produced dose-dependent decreases in heart rate and blood pressure of rabbits and rats. Potentiation of adenosine action by intravenous infusion of dipyridamole occurred only in rabbits. When administered into the renal artery of pigs, dogs, rabbits, and rats, adenosine caused dose-dependent vasoconstriction in all species, whereas dipyridamole produced vasoconstriction in rabbits and vasodilation in pigs and rats. In dogs, the renal vascular response to dipyridamole depended on the perfusion method used. In kidneys perfused at a fixed flow rate with a pump, intrarenal dipyridamole elicited vasoconstriction, but in kidneys perfused by their own systemic blood pressure without the use of a pump, it caused vasodilation. The adenosine-induced renal vasoconstriction was enhanced by dipyridamole in pigs, dogs, and rabbits, but not in rats. Species differences and the perfusion method used are important for the renal vascular effects of dipyridamole. Dipyridamole appears to possess not only an indirect ...Continue Reading

Citations

Jan 1, 1988·The International Journal of Biochemistry·P MeghjiA C Newby
Jan 1, 1983·Journal of Neurosurgery·N F KassellJ A Sprowell
Jan 1, 1983·Journal of Neurosurgery·N F KassellJ J Olin
Mar 1, 1987·British Journal of Clinical Pharmacology·P SeidemanB B Fredholm
Jun 9, 2016·Autonomic Neuroscience : Basic & Clinical·Geoffrey Burnstock, Andrzej Loesch
Nov 1, 1982·Stroke; a Journal of Cerebral Circulation·D J BoariniJ A Sprowell
Dec 18, 2013·Pharmacological Reviews·Geoffrey Burnstock, Vera Ralevic

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