Species differences in the carbohydrate binding preferences of surfactant protein D

American Journal of Respiratory Cell and Molecular Biology
Erika CrouchK L Hartshorn

Abstract

Interactions of surfactant protein D (SP-D) with micro-organisms and organic antigens involve binding to the trimeric neck plus carbohydrate recognition domain (neck+CRD). In these studies, we compared the ligand binding of homologous human, rat, and mouse trimeric neck+CRD fusion proteins, each with identical N-terminal tags remote from the ligand-binding surface. Although rat and mouse showed similar affinities for saccharide competitors, both differed markedly from the human protein. The human neck+CRD preferentially recognized N-acetyl-mannosamine, whereas the rat and mouse proteins showed greater affinity for myoinositol, maltose, and glucose. Although human neck+CRDs bound to maltosyl-agarose and fungal mannan, only rat and mouse neck+CRDs showed significant binding to maltosyl-Toyopearl beads, solid-phase maltosyl-albumin neo-glycoprotein, or the Phil82 strain of influenza A virus. Likewise, human SP-D dodecamers and trimeric subunits of full-length rat, but not full-length human SP-D trimers, bound to maltosyl-Toyopearl. Site-directed mutagenesis of the human neck+CRD demonstrated an important role of Asp324-Asp325 in the recognition of N-acetyl-mannosamine, and substitution of the corresponding murine sequence (Asn324-...Continue Reading

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Citations

Mar 17, 2010·The Journal of Biological Chemistry·Erika C CrouchAzzaq Belaaouaj
Jun 8, 2007·Journal of Virology·David J VigerustJonathan A McCullers
Oct 20, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kevan L HartshornErika C Crouch
Oct 2, 2012·American Journal of Respiratory Cell and Molecular Biology·J Michael StolleyEileen Remold-O'Donnell
Feb 10, 2010·Medical Mycology·Scarlett Geunes-BoyerWilliam J Steinbach
Jun 10, 2011·The FEBS Journal·Edwin J A VeldhuizenHenk P Haagsman
Jun 6, 2012·Journal of Biomedicine & Biotechnology·Wy Ching NgPatrick C Reading
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Apr 29, 2010·Innate Immunity·Barbara A SeatonRichard Mendelsohn
Feb 8, 2018·The Journal of Biological Chemistry·Sarah Sze Wah WongVishukumar Aimanianda
Feb 24, 2018·Frontiers in Medicine·Grith L Sorensen
May 18, 2018·The Journal of Biological Chemistry·Martin van EijkHenk P Haagsman
Jul 6, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kevan L HartshornErika C Crouch
Jul 20, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Michelle D TatePatrick C Reading
Oct 4, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Dalia FakihGrith L Sorensen
Nov 20, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mitchell WhiteKevan Hartshorn

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