Species differences in the induction of time-dependent potentiation of insulin secretion

Endocrinology
W S Zawalich, K C Zawalich

Abstract

The secretory responsiveness of the pancreatic beta-cell can be markedly improved by prior short term exposure to a stimulatory glucose level. Termed time-dependent potentiation (TDP), priming, or sensitization, this phenomenon has been documented to occur in both human and rat islets and my involve, at least in part, information flow in the phospholipase C and protein kinase C (PKC) signal transduction pathway. In contrast to human and rat islets, however, mouse islets fail to exhibit TDP in response to priming with high glucose. In the present series of studies, we explored in more detail the conditions and stimulants necessary for the induction of TDP in mouse islets and compared these responses with those obtained in rat islets. In agreement with previous reports, high (15 mM) glucose alone primed the rat beta-cell, but not the mouse beta-cell, to subsequent restimulation with 15 mM glucose. However, muscarinic stimulation of mouse islets with carbachol (100 microM) in the presence of 15 mM glucose primed the beta-cell to a subsequent 15-mM glucose stimulus. In addition, prior exposure to 50 nM of the PKC activator tetradecanoyl phorbol acetate dramatically amplified the subsequent insulin secretory responses of mouse islet...Continue Reading

Citations

Apr 25, 2012·Life Sciences·Inigo Ruiz de AzuaJürgen Wess
Nov 26, 2010·Trends in Endocrinology and Metabolism : TEM·Inigo Ruiz de AzuaJürgen Wess
Dec 7, 2002·Diabetes/metabolism Research and Reviews·Susanne G Straub, Geoffrey W G Sharp
Aug 18, 2005·American Journal of Physiology. Endocrinology and Metabolism·Hanae YamazakiWalter S Zawalich
Jul 27, 2006·American Journal of Physiology. Endocrinology and Metabolism·Hanae YamazakiWalter S Zawalich
Apr 17, 2008·American Journal of Physiology. Endocrinology and Metabolism·Subhadra C GunawardanaDavid W Piston
Sep 22, 2015·Frontiers in Physiology·Olga NikitidouVassilios Liakopoulos
Apr 5, 2001·American Journal of Physiology. Endocrinology and Metabolism·W S ZawalichW M Philbrick
Apr 1, 1997·The American Journal of Physiology·W S Zawalich, K C Zawalich
Dec 9, 1998·The American Journal of Physiology·W S ZawalichK C Zawalich

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