Species differences in the metabolism of pamatolol, a cardioselective beta--adrenoceptor antagonist

European Journal of Drug Metabolism and Pharmacokinetics
K J HoffmannK O Borg

Abstract

The metabolism of pamatolol was studied in man, dogs, rats and mice after oral administration of a single dose. The drug was well absorbed in the gastro-intestinal tract and excreted in the urine, mainly in unchanged form, within 24 hrs. Four urinary metabolites were identified by gas chromatographic-mass spectrometric techniques. The metabolic data, in man, dog and mouse was found to be similar, both qualitatively and quantitatively. One metabolism route, involving aliphatic hydroxylation and subsequent oxidation, was found, to a significant extent only in the rat. The species variation between the mouse and the rat with regard to long-term toxicity of pamatolol is discussed. Artefact formation during trace analysis was observed.

References

Nov 1, 1986·The British Journal of Nutrition·C L FerrellJ A Nienaber
May 20, 2019·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Paul OosterveldNiels Smits

Citations

May 1, 1978·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·P R ReevesM J Winrow
Aug 1, 1978·Clinical Pharmacology and Therapeutics·S G CarruthersD L Azarnoff
Feb 1, 1979·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·K J HoffmannI Skånberg
Nov 1, 1978·Biomedical Mass Spectrometry·K J HoffmannI Skånberg
Nov 1, 1976·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A ArfwidssonI Skånberg
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J McCannB N Ames
Aug 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·B N AmesF D Lee
Aug 1, 1974·Journal of Pharmacokinetics and Biopharmaceutics·C G RegårdhL Palmer
Aug 1, 1974·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·A H Beckett, P M Bélanger
Jul 1, 1974·Journal of Pharmaceutical Sciences·D G Kaiser, S R Shaw

Related Concepts

Metabolic Process, Cellular
Urine
Antagonist Muscle Action
Oxidation
Propanolamines
Mass Spectrometry
Entire Intestinal Tract
Metabolic Pathway
Adrenergic Receptor
Chromatography, Gas-Liquid

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.