Species differences in the projections from the entorhinal cortex to the hippocampus

Brain Research Bulletin
T Van GroenJ M Wyss

Abstract

Both differences and similarities exist between mammalian species in the projections from entorhinal cortex to the hippocampal formation. In most species, layer II cells of the entorhinal cortex project to the dentate gyrus, and they terminate in the outer two-thirds of the molecular layer of the dentate gyrus. The axons from layer III cells project bilaterally to areas CA(1) and CA(3) of the hippocampus, terminating in the stratum lacunosum moleculare. We have analyzed these projections in mice, and in general, the entorhinal cortex-to-hippocampus projections are similar to those in rats. Axons from layer II neurons terminate in the outer and middle thirds of the molecular layer of the dentate gyrus, and axons from layer III neurons terminate bilaterally in the stratum lacunosum moleculare of areas CA(1) and CA(3), and in the molecular layer of the subiculum. However, in contrast to rat, mouse entorhinal cortex neurons do not appreciably project to the contralateral dentate gyrus. Most species, including mice, show a similar topographical organization of the entorhinal-hippocampal projections, with neurons in the lateral part of both the lateral and medial entorhinal cortex projecting to the dorsal part or septal pole of the h...Continue Reading

References

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Citations

May 12, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jin-Bo DengMing-Shan Li
May 19, 2006·The European Journal of Neuroscience·Farima BouzioukhValérie Castellani
Aug 26, 2006·The European Journal of Neuroscience·Samuel S NewtonRonald S Duman
Mar 26, 2016·Frontiers in Neuroanatomy·R Maarten van DijkIrmgard Amrein
Mar 2, 2016·Synapse·Amelia L GallitanoDiano F Marrone
Aug 2, 2006·Hippocampus·Joseph R Manns, Howard Eichenbaum
Aug 5, 2010·Hippocampus·Catherine E Myers, Helen E Scharfman
Dec 6, 2011·Biochemical and Biophysical Research Communications·Kyounghee RyuTomoo Hirano
May 9, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Sara ChavoshinezhadLeila Dargahi
Nov 6, 2008·Journal of Physiology, Paris·Günther K H Zupanc

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