PMID: 9434282Jan 22, 1998Paper

Species differences of serum albumins: I. Drug binding sites

Pharmaceutical Research
T KosaM Otagiri

Abstract

The purpose of this study was the classification and identification of drug binding sites on albumins from several species in order to understand species differences of both drug binding properties and drug interaction on protein binding. Binding properties and types of drug-drug interaction on the different albumins were examined using typical site I binding drugs, warfarin (WF) and phenylbutazone (PBZ), and site II binding drugs, ibuprofen (IP) and diazepam (DZ) on human albumin. Equilibrium dialysis was carried out for two drugs and the free concentrations of drugs were then treated using the methods of Kragh-Hansen (Mol. Pharmacol. 34. 160-171, (1988)). Binding affinities of site I drugs to bovine, rabbit and rat albumins were reasonably similar to human albumin. However, interestingly, those to dog albumin were considerably smaller than human albumin. On the other hand, binding parameters of DZ to bovine, rabbit and rat albumins were apparently different from those of human albumin. These differences are best explained by microenvironmental changes in the binding sites resulting from change of size and/or hydrophobicity of the binding pocket, rather than a variation in amino acid residues. CONCLUSIONS. We will propose here...Continue Reading

Citations

Nov 8, 2005·Drug Metabolism and Pharmacokinetics·Masaki Otagiri
Apr 2, 2009·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Masaki Otagiri
Jul 30, 2011·Biopharmaceutics & Drug Disposition·Haiyan LiJiwen Zhang
Jul 15, 2011·Luminescence : the Journal of Biological and Chemical Luminescence·Mengyao HuGongwu Song
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