Species fractionation in a case-control study concerning Parkinson's disease: Cu-amino acids discriminate CSF of PD from controls

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
Desiree WillkommenBernhard Michalke

Abstract

Parkinson's disease is affecting about 1% of the population above 65 years. Improvements in medicine support prolonged lifetime which increases the total concentration of humans affected by the disease. It is suggested that occupational and environmental exposure to metals like iron (Fe), manganese (Mn), copper (Cu) and zinc (Zn) can influence the risk for Parkinson's disease. These metals play a key role as cofactors in many enzymes and proteins. In this case-control study, we investigated the Mn-, Fe-, Cu- and Zn-species in cerebrospinal fluid (CSF) by size-exclusion chromatography hyphenated to inductively coupled plasma mass spectrometry (SEC-ICP-MS) and the total concentration of these metals by inductively coupled plasma sector field mass spectrometry (ICP-sf-MS). The investigation of total metal concentration and speciation provided only minor changes, but it produced strong significance for a number of ratios. The analysis revealed a strong change in the ratio between total concentration of Fe and the amino acid-fraction of Cu. This could be observed when analyzing both the respective element concentrations of the fraction (which also depends on individual variation of the total element concentration) as well as when be...Continue Reading

Citations

Jul 4, 2019·Neurotoxicity Research·Alika SarkarMahendra Pratap Singh
Dec 24, 2019·Frontiers in Aging Neuroscience·Marianna LucioBernhard Michalke
Nov 26, 2020·Metallomics : Integrated Biometal Science·Jemmyson Romário de Jesus, Marco Aurélio Zezzi Arruda
Oct 25, 2020·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Félix Javier Jiménez-JiménezJosé A G Agúndez
Mar 17, 2021·Biological Trace Element Research·Sergey A MiroshnikovAlexey A Tinkov
May 19, 2021·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Olga P AjsuvakovaAnatoly V Skalny

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