Species-related variations in antioxidant components of gastric and duodenal mucosa

Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
M H Moghadasian, D V Godin

Abstract

Enzymatic and non-enzymatic antioxidant profiles of the gastric and duodenal mucosa of rat, rabbit, cat and pig were investigated and found to exhibit significant variations. Rat gastric and duodenal mucosa exhibited the highest levels of basal glutathione of the various tissues examined. The highest activity of glutathione reductase was found in the gastric and duodenal mucosa of rat as compared with that in these tissues from the other species. The gastric mucosa of cat and pig showed similar activities of glutathione peroxidase, which was significantly lower than those in rat or rabbit gastric mucosa. The activity of this antioxidant enzyme was similar in rat, rabbit and pig duodenal mucosa and lower than that in cat duodenal mucosa. Strong correlations were found between activities of the functionally coupled antioxidant enzymes glutathione peroxidase and glutathione reductase in gastric but not in duodenal mucosa. The activity of superoxide dismutase showed negligible regional or species-related variations in activity.

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Citations

Feb 9, 1996·Molecular and Cellular Biochemistry·M H Moghadasian, D V Godin
Apr 1, 1996·Digestive Diseases and Sciences·M H Moghadasian, D V Godin
Nov 30, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ilaria PelusoMaura Palmery
Dec 1, 2001·Biological & Pharmaceutical Bulletin·T VovkM Schara
Nov 14, 1998·The American Journal of Physiology·C G SobeyF M Faraci

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