Specific alteration of rhythm in temperature-stressed rats possess features of abdominal pain in IBS patients

Journal of Pharmacological Sciences
Yasuo ItomiYasuhiro Tsukimi

Abstract

It is known that specific alteration of rhythm in temperature (SART) stress produces somatic pain. However, it remains to be investigated whether SART stress induces visceral pain. In this study, we investigated the visceral hypersensitivity in the SART stress model by pharmacological tools and heterotopical nociception. Four-week-old Sprague-Dawley rats were exposed to repeated cold stress. Visceral pain was measured by visceromotor response to colorectal distension, and the effects of alosetron and duloxetine on visceral pain were investigated in SART rats. Heterotopical nociception was given by capsaicin injection into the left forepaw to induce diffuse noxious inhibitory controls (DNIC). SART stress induced visceral hypersensitivity that was sustained at minimum for one week. In pharmacological analysis, alosetron and duloxetine improved SART stress-induced visceral hypersensitivity. Heterotopical nociception induced DNIC in normal conditions, but was disrupted in SART rats. On the other hand, RMCP-II mRNA in distal colon was not affected by SART stress. In conclusion, SART rats exhibit several features of visceral pain in IBS, and may be a useful model for investigating the central modification of pain control in IBS.

References

Jun 22, 2002·Gut·G BarbaraR Corinaldesi
Feb 19, 2003·Brain Research. Brain Research Reviews·Daniel Le Bars
Nov 5, 2003·Expert Opinion on Pharmacotherapy·Emeran A Mayer, Sylvie Bradesi
Jul 16, 2004·The Journal of Pharmacology and Experimental Therapeutics·Smriti IyengarRosa Maria A Simmons
Mar 5, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sylvie BradesiEmeran A Mayer
Jan 8, 2008·The Journal of Veterinary Medical Science·Katsuyo OhashiYoichi Kurebayashi
Jul 17, 2008·Current Gastroenterology Reports·Roberto De Giorgio, Giovanni Barbara
Jun 24, 2009·Human Psychopharmacology·Brian P BrennanJames I Hudson
Jan 16, 2010·The Journal of Pain : Official Journal of the American Pain Society·Gerrit van Wijk, Dieuwke S Veldhuijzen
Sep 8, 2010·The Journal of Clinical Psychiatry·Edith NormandSerge Marchand
Oct 15, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Luiz F FerrariJon D Levine
Feb 19, 2011·Journal of Gastroenterology·Alexander C Ford, Nicholas J Talley

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Citations

Dec 15, 2015·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T NozuT Okumura
May 15, 2016·European Journal of Pharmacology·Yasuo ItomiToru Kawamura
Jan 24, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Yasuo ItomiYasuhiro Tsukimi

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