PMID: 7543214Jul 1, 1995Paper

Specific and long-lasting protection from collagen-induced arthritis and oil-induced arthritis in DA rats by administration of immunogens

Scandinavian Journal of Immunology
J C LorentzenL Klareskog

Abstract

DA rats develop transient arthritis after subcutaneous immunization with adjuvant-oil, while chronic arthritis and collagen autoreactivity ensues when collagen is added to the oil. We show here that DA rats can be protected from oil-induced arthritis (OIA) and rat collagen-induced arthritis (rCIA) by addition of antigen to these arthritogenic inocula. We have investigated this remarkable phenomenon and demonstrate that both foreign and self antigens can be protective, apparently provided they are immunogenic; hence HSP-65kDa, ovalbumin, rat myelin basic protein, rat IgG and bovine albumin are effective while rat albumin is not. This protection is long-lasting and disease-specific because rats protected from rCIA resist a later attempt to induce arthritis, but not experimental autoimmune encephalomyelitis (EAE). Protection from rCIA depends neither on the blocking of humoral autoreactivity to collagen nor on a change in the isotype profile of anti-collagen antibodies. We demonstrate that immunogens can also be protective when injected intraperitoneally only a few days before onset of arthritis. Our results indicate that protection is mediated through bystander immune reactions towards the co-immunized antigen and that the arthri...Continue Reading

References

Jun 1, 1979·Agents and Actions·Y H Chang, M L Bliven
Jan 1, 1975·Archives of Biochemistry and Biophysics·B D SmithR Swarm
Jul 1, 1992·Scandinavian Journal of Immunology·J S EllisD R Katz
Sep 1, 1988·International Reviews of Immunology·M M Griffiths
Jun 1, 1967·Arthritis and Rheumatism·I Gery, B H Waksman
Jan 1, 1956·Proceedings of the Society for Experimental Biology and Medicine·C M PEARSON
Jul 1, 1965·Proceedings of the Society for Experimental Biology and Medicine·K ISAKOVIC, B H WAKSMAN
Sep 1, 1994·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·T Olsson

❮ Previous
Next ❯

Citations

Feb 19, 1999·Scandinavian Journal of Immunology·J C Lorentzen
Mar 21, 2002·Scandinavian Journal of Immunology·L SvelanderJ C Lorentzen
Sep 1, 1995·Journal of Internal Medicine·L KlareskogG Holm
Apr 3, 2004·Arthritis Research & Therapy·N Fredrik Bäckström, Ulf I H Dahlgren
Jun 15, 2000·The American Journal of Pathology·B C CarlsonJ C Lorentzen
Jan 30, 2008·Scandinavian Journal of Immunology·N F Bäckström, U I H Dahlgren
Dec 21, 2000·Clinical and Experimental Immunology·L MattssonR A Harris
Jun 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Md Younus MiaKamal D Moudgil

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.