Specific and unspecific removal of circulating noradrenaline in pulmonary and systemic vascular beds in man.

Acta Physiologica Scandinavica
L StjärneG Birke

Abstract

In order to study the extent and degree of specificity of the removal of circulating noradrenaline (NA) from the blood stream, during a single passage through the vascular beds of the lungs and of the forearm musculature of unanaesthetized, healthy young men, the following radiometric method was used: A misture of 3H-NA with 14C-inulin and 125I-labelled human serum albumin was injected proximally to the bed under study; six serial blood smaples were drawn distally to it, with about 15 s interval, and the disappearance of 3H-NA relatively to that of 14C-inulin and 125I-albumin was determined. 3H-NA was found to be removed from the blood stream in both these vascular beds. However, in the forearm the removal of 3H-NA was much greater, and apparently to a large extent due to specific trapping in the tissues, since the clearance of 3H-NA over the vascular bed of the forearm markedly exceeded that of 14C-inulin. During passage through the lungs removal of 3H-NA was less marked, and apparently largely unspecific, since it was initially essentially equal to that of 14C-inulin. This suggests that removal of circulating ergones of small molecular size, from the blood stream passing through the lungs, may occur initially by unspecific fi...Continue Reading

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Citations

Mar 1, 1983·The Journal of Clinical Investigation·J HilstedS Madsbad
Dec 1, 1976·Biochemical Pharmacology·C N Gillis, J A Roth
Sep 1, 1986·Hypertension·P C ChangP van Brummelen
Jul 1, 1991·Hypertension·P C ChangP van Brummelen

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