Specific antagonists of platelet activating factor-mediated vasoconstriction and glycogenolysis in the perfused rat liver

Biochemical Pharmacology
D B BuxtonM S Olson

Abstract

Stimulation of hepatic glycogenolysis and vasoconstriction of the hepatic vasculature in response to acetyl glyceryl ether phosphocholine (AGEPC; platelet activating factor) was inhibited by two structural analogues of AGEPC, U66985 (1-O-octadecyl-2-O-acetyl-sn-glycero-3-phosphoric acid-6'-trimethyl ammonium hexyl ester) and CV3988 [rac-3-(N-n-octadecylcarbamoyloxy)-2-methoxy-propyl-2-thiazolioethyl+ ++ phosphate]. Infusion of CV3988, 10(-7) M, increased the AGEPC dose needed for half-maximal hemodynamic response by approximately 5-fold, while U66985 at 10(-7) M increased by twenty times the dose of AGEPC required to give the half-maximal response. Glucose output responses were similarly inhibited. U66985, 10(-6) M, completely abolished both hemodynamic and glycogenolytic responses to AGEPC, 2 X 10(-10) M, while in the presence of CV3988, 10(-6) M, approximately 15% of the uninhibited responses remained. Perfusion of livers for 20 min after termination of inhibitor infusion, in the absence or presence of bovine serum albumin, resulted in only a slightly smaller extent of inhibition than simultaneous infusion of agonist and antagonist. Specificity of the inhibitors was demonstrated by only a minimal inhibition of glycogenolytic ...Continue Reading

References

Jul 15, 1984·Experientia·G CamussiG Emanuelli
Mar 1, 1984·The Journal of Pharmacy and Pharmacology·A TokumuraH Tsukatani
Apr 25, 1983·Life Sciences·Z TerashitaK Nishikawa
Oct 15, 1984·European Journal of Pharmacology·P IñarreaM S Crespo
Sep 1, 1983·British Journal of Pharmacology·J BenvenisteC Labat
Dec 9, 1983·European Journal of Pharmacology·J Björk, G Smedegård
Jan 21, 1983·European Journal of Pharmacology·P BessinJ Benveniste
Mar 1, 1983·Acta Physiologica Scandinavica·E E MuirheadP Thoren
Jan 1, 1981·Annals of the New York Academy of Sciences·B B VargaftigF Wal
Sep 1, 1981·The American Journal of Physiology·S R FindlayR N Pinckard

❮ Previous
Next ❯

Citations

Sep 1, 1996·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·C R GandhiJ Fung
Nov 25, 1988·Biochimica Et Biophysica Acta·R KumarM S Olson
Jan 1, 1990·Pharmacology & Therapeutics·F Ballet
May 1, 1995·Pharmacology & Therapeutics·M Pinzani
Aug 1, 1986·Pharmacological Research Communications·M Sanchez CrespoS Fernandez-Gallardo
Dec 1, 1989·Resuscitation·D HosfordP Braquet
Jul 19, 2006·Prostaglandins & Other Lipid Mediators·Sen CuiYasutaka Kurata
Dec 31, 1997·Prostaglandins, Leukotrienes, and Essential Fatty Acids·H G WangS Koyama
Sep 1, 1991·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R D EvansD H Williamson
Jan 12, 2008·World Journal of Gastroenterology : WJG·Yan ChenYong-Ping Yang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Biochemical and Biophysical Research Communications
J A García-Sáinz, S M Hernández-Sotomayor
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
D S Lapointe, M S Olson
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
F GuarnerJ Rodés
Prostaglandins, Leukotrienes, and Essential Fatty Acids
H G WangS Koyama
© 2021 Meta ULC. All rights reserved