PMID: 7013968Mar 15, 1981Paper

Specific antiemetics for specific cancer chemotherapeutic agents: haloperidol versus benzquinamide

Cancer
J A NeidhartH E Wilson

Abstract

Sixty-four patients receiving cancer chemotherapy known to induce severe emesis entered a randomized double-blind study of the antiemetic efficacy of haloperidol (Haldol) and benzquinamide (Emetecon). Patients preferred haloperidol for control of emesis induced by cis-platinum (78 vs. 22%) or nitrogen mustard (67 vs. 16%). Patients receiving Doxorubicin preferred benzquinamide by a small margin (46 to 38%). Individual patients who experienced no relief with their first antiemetic (13 of 15) usually got some relief with the other after crossover. Haloperidol was more effective than benzquinamide (54 vs. 29%) in patients previously unrelieved by prochlorperazine (Compazine). Complete relief of vomiting was obtained in 14 of 45 patients receiving haloperidol but only five of 41 patients receiving benzquinamide experienced no vomiting, again dependent on the anticancer agent used. Although haloperidol is a more effective antiemetic agent overall, efficacy is related to the anticancer treatment and probably to individual patient characteristics.

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Citations

Jan 1, 1984·Cancer Chemotherapy and Pharmacology·F CognettiC F Pollera
Jan 1, 1981·Psychopharmacology·C J NiemegeersP A Janssen
Jan 1, 1984·Molecular Aspects of Medicine·J H Barnes
Apr 19, 2008·Anesthesia and Analgesia·Carl E RosowEdward A Bittner
Jan 1, 1984·Cancer Investigation·J J Fiore, R J Gralla
Jan 1, 1987·The American Journal of the Medical Sciences·J B Craig, B L Powell
Dec 1, 1982·Cancer Treatment Reviews·J Laszlo
Jun 1, 1985·Journal of Clinical and Hospital Pharmacy·L J Dodds
May 1, 2013·Journal of Pain & Palliative Care Pharmacotherapy·Samantha L McLeanMichael I Bennett
Dec 1, 1984·Cancer·H J Eyre, J H Ward
Nov 3, 2015·The Cochrane Database of Systematic Reviews·Fay Murray-Brown, Saskie Dorman
Jul 10, 1982·The Medical Journal of Australia·R D ArnottM Cohen

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