PMID: 2121521Sep 17, 1990Paper

Specific binding of sulphated polymers to ram sperm proacrosin

FEBS Letters
R M Williams, R Jones

Abstract

Sulphated polysaccharides and zona pellucida glycoproteins have been shown to bind non-enzymatically to proacrosin, the protein found within the acrosomal vesicle of mammalian spermatozoa. The mechanism of this interaction has been investigated using 125I-fucoidan to probe purified ram sperm proacrosin. Results show that (a) binding of 125I-fucoidan to proacrosin is inhibited only by sulphated polymers and (b) recognition is mediated by poly(sulphate) groups and is largely independent of the composition of the polymer chain. It is suggested that a similar mechanism is responsible for the interaction between proacrosin and zona pellucida glycoproteins during the early stages of fertilization in mammals and this process mediates firm binding of spermatozoa to the egg.

References

Jan 19, 1990·Biochimica Et Biophysica Acta·P L DeAngelis, C G Glabe
Aug 1, 1988·Biological Chemistry Hoppe-Seyler·U A Urch, J L Hedrick
Jan 30, 1987·Science·P M Wassarman
Aug 1, 1987·Experimental Cell Research·R Jones, C R Brown
Nov 1, 1987·Cell Biology International Reports·R Jones
Nov 1, 1988·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·H J Hathaway, B D Shur
Oct 18, 1988·Biochemistry·P L DeAngelis, C G Glabe
Dec 21, 1987·FEBS Letters·E Töpfer-Petersen, A Henschen
Jun 1, 1987·Developmental Biology·J L Hedrick, N J Wardrip
Apr 15, 1983·Analytical Biochemistry·C G GlabeS D Rosen
Dec 1, 1980·Hoppe-Seyler's Zeitschrift für physiologische Chemie·R Fock-NüzelH Fritz
Jan 1, 1948·Acta Chemica Scandinavica·E VASSEUR

❮ Previous
Next ❯

Citations

May 23, 2015·Asian Journal of Andrology·Nongnuj TanphaichitrMark Baker
May 15, 1993·The Journal of Experimental Zoology·R M Williams, R Jones
May 10, 1994·Biochemistry·J M HermansS R Stone

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.