Specific binding structures of dendrimers on lipid bilayer membranes

Physical Chemistry Chemical Physics : PCCP
Yong-Lei WangAatto Laaksonen

Abstract

Dissipative particle dynamics simulations are used to study the specific binding structures of polyamidoamine (PAMAM) dendrimers on amphiphilic membranes and the permeation mechanisms. Mutually consistent coarse-grained (CG) models both for PAMAM dendrimers and for dimyristoylphosphatidylcholine (DMPC) lipid molecules are constructed. The PAMAM CG model describes correctly the conformational behavior of the dendrimers, and the DMPC CG model can properly give the surface tension of the amphiphilic membrane. A series of systematic simulations is performed to investigate the binding structures of the dendrimers on membranes with varied length of the hydrophobic tails of amphiphiles. The permeability of dendrimers across membranes is enhanced upon increasing the dendrimer size (generation). The length of the hydrophobic tails of amphiphiles in turn affects the dendrimer conformation, as well as the binding structure of the dendrimer-membrane complexes. The negative curvature of the membrane formed in the dendrimer-membrane complexes is related to dendrimer concentration. Higher dendrimer concentration together with increased dendrimer generation is observed to enhance the permeability of dendrimers across the amphiphilic membranes.

References

Sep 28, 1990·Science·R Langer
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·J F Kukowska-LatalloJ R Baker
Jun 20, 1997·Science·D A EdwardsR Langer
Dec 6, 2001·Advanced Drug Delivery Reviews·A RöslerH A Klok
Dec 18, 2001·Advanced Drug Delivery Reviews·Y Qiu, K Park
Feb 19, 2002·Chemical Reviews·A. W. BosmanE. W. Meijer
Sep 28, 2002·Nature·James D MartinLennox Iton
Jan 23, 2004·Chemical Society Reviews·Ulrik Boas, Peter M H Heegaard
Apr 20, 2004·Physical Review Letters·Live RekvigBerend Smit
May 19, 2004·Nucleic Acids Research·Maria ManuntaAndrew J T George
Jun 19, 2004·Drug Delivery·Giulio F PaciottiLawrence Tamarkin
Aug 13, 2004·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·A AlSunaidiJ H R Clarke
Nov 9, 2004·Chemistry and Physics of Lipids·Almut MeckeMark M Banaszak Holl
Feb 16, 2005·Nature Materials·Julian C Shillcock, Reinhard Lipowsky
Sep 7, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Almut MeckeMark M Banaszak Holl
Oct 29, 2005·The Journal of Chemical Physics·Juan J FreireAna M Rubio
Nov 3, 2005·Langmuir : the ACS Journal of Surfaces and Colloids·Almut MeckeBradford G Orr
Nov 29, 2005·Advanced Drug Delivery Reviews·Christine DufèsAndreas G Schätzlein
Jan 27, 2006·Nature·Alain Reza Yavari
Mar 11, 2006·The Journal of Chemical Physics·Andrey A GurtovenkoIlpo Vattulainen
Jun 2, 2006·Nature Materials·David Putnam
Jul 21, 2006·The Journal of Physical Chemistry. B·Marieke Kranenburg, Berend Smit
Sep 15, 2006·The Journal of Physical Chemistry. B·Hwankyu Lee, Ronald G Larson
Dec 21, 2006·The Journal of Chemical Physics·Minerva González-MelchorJosé Alejandre
Dec 22, 2006·The Journal of Physical Chemistry. B·Prabal K Maiti, William A Goddard
May 4, 2007·Accounts of Chemical Research·Pascale R LeroueilMark M Banaszak Holl
Oct 13, 2007·Physical Review Letters·Hu-Jun QianZe-Sheng Li
Jan 26, 2008·Nano Letters·Pascale R LeroueilMark M Banaszak Holl
May 20, 2008·Biophysical Journal·Frédérick Jean-Marie de MeyerBerend Smit
Jul 16, 2008·The Journal of Physical Chemistry. B·Christopher V KellyIoan Andricioaei
Jul 16, 2008·The Journal of Physical Chemistry. B·Christopher V KellyIoan Andricioaei
Sep 4, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Blake EricksonMark M Banaszak Holl
Dec 23, 2008·Chemical Reviews·Rakesh Kumar TekadeNarendra Kumar Jain
Feb 10, 2009·Journal of the American Chemical Society·Yi LiuWilliam A Goddard
Feb 20, 2009·Proceedings of the National Academy of Sciences of the United States of America·Frédérick de Meyer, Berend Smit
Apr 17, 2009·The Journal of Chemical Physics·Prabal K MaitiWilliam A Goddard
Jun 19, 2009·ACS Nano·Christopher V KellyMark M Banaszak Holl
Jul 9, 2009·Bioconjugate Chemistry·Seungpyo HongMark M Banaszak Holl

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Citations

Mar 29, 2014·Soft Matter·Yiyun ChengTianfu Li
Dec 11, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nuno MartinhoTeresa Barata
Nov 18, 2015·Journal of Chemical Theory and Computation·Ming-Tsung LeeAlexander V Neimark
Mar 2, 2016·Biochimica Et Biophysica Acta·M RamezanpourD P Tieleman
Nov 2, 2012·Chemical Society Reviews·Wen-de Tian, Yu-qiang Ma
Dec 12, 2012·Physical Chemistry Chemical Physics : PCCP·Edroaldo Lummertz da RochaCarlos Renato Rambo
Mar 8, 2013·The Journal of Physical Chemistry. B·Kan YangAlexander V Neimark
Jun 3, 2014·The Journal of Physical Chemistry. B·Yongbin KimRakwoo Chang
Jul 11, 2013·The Journal of Physical Chemistry. B·Ming-Tsung LeeAlexander V Neimark
Nov 1, 2012·The Journal of Physical Chemistry Letters·Aleksey VishnyakovAlexander V Neimark

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