Specific brain proteins during severe ethanol intoxication and withdrawal in the rat

Psychiatry Research
R Hemmingsen, O S Jørgensen

Abstract

In a study of the effects of severe chronic ethanol intoxication and withdrawal, immunoelectrophoretic measurements were made of the specific nervous system proteins D1, D2, D3, synaptin, 14-3-2, and glutamine synthetase in the brain. During chronic ethanol intoxication, none of these proteins deviated significantly from normal values, so the structural background for neuronal function was not measurably disturbed by any toxic effect of ethanol. However, during the ethanol withdrawal reaction, the specific concentrations of neuronal proteins D1, D2, 14-3-2, and synaptin were increased, and they subsequently normalized. D3 in brain and D2 in cerebrospinal fluid were decreased and subsequently normalized. When the neuronal localization and the possible function of these proteins are considered, the results may be interpreted as indicating an increased synthesis of neuronal synapses during the ethanol withdrawal reaction accompanied by a transient halt in synaptic decomposition. No changes occurred in the glial marker glutamine synthetase, and thus the measured changes in specific brain protein concentrations apparently reflect the structural dynamics of establishing the substrate for the functional neuronal hyperactivity constitu...Continue Reading

References

Mar 25, 1977·Science·A Martinez-HernandezM D Norenberg
Feb 2, 1979·Brain Research·M D Norenberg, A Martinez-Hernandez
Apr 1, 1979·Acta Psychiatrica Scandinavica·R HemmingsenO J Rafaelsen
Jul 1, 1979·Acta Physiologica Scandinavica·R Hemmingsen, D I Barry
Jul 1, 1977·Acta Psychiatrica Scandinavica·O S JorgensenO J Rafaelsen
Jan 20, 1978·Science·D SchmechelF K Goodwin
Jan 1, 1978·Journal of Neurochemistry·E Bock
Aug 17, 1979·Science·O S Jorgensen, T G Bolwig
Nov 23, 1979·Biochimica Et Biophysica Acta·O Jørgensen
May 1, 1977·Drug and Alcohol Dependence·W R MartinC A Haertzen
Oct 1, 1974·Journal of Neurochemistry·O S Jorgensen, E Bock
Sep 1, 1974·Journal of Neurochemistry·W A Hunt, E Majchrowicz
Jan 1, 1973·Scandinavian Journal of Immunology. Supplement·B Weeke
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Jun 1, 1980·Journal of Neurochemistry·R Hemmingsen, A G Chapman
Nov 1, 1976·Journal of Neurochemistry·O S Jørgensen
Jan 1, 1954·Archiv für Psychiatrie und Nervenkrankheiten, vereinigt mit Zeitschrift für die gesamte Neurologie und Psychiatrie·G HUBER

❮ Previous
Next ❯

Citations

Jan 1, 1982·Journal of Neural Transmission·O S JørgensenK Jellinger
Jan 1, 1985·Journal of Neural Transmission·O S Jørgensen, P Riederer
Aug 1, 1990·Journal of the Neurological Sciences·O S JørgensenR Balázs
Jun 1, 1994·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·O S Jørgensen
Feb 1, 1990·Alcoholism, Clinical and Experimental Research·D J Bonthius, J R West
May 1, 1984·Brain Research·O S JørgensenJ M Matthieu
Apr 1, 1997·Experimental Neurology·O S JørgensenD G Stein
Jan 1, 1988·Acta Psychiatrica Scandinavica. Supplementum·O S Jørgensen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.