PMID: 11902823Mar 21, 2002Paper

Specific bronchoalveolar lavage fluid T cells associate with disease in a pair of monozygotic twins discordant for sarcoidosis

Journal of Internal Medicine
I Grunewald, Anders Eklund

Abstract

A 49-year-old Caucasian woman had an acute onset of sarcoidosis. Bronchoscopy with bronchoalveolar lavage (BAL) showed a pronounced accumulation of BAL fluid CD4+ T cells expressing the T-cell receptor (TCR) AV2S 3 gene. In line with this observation, the patient was HLA-DR 17 positive, previously shown to strongly correlate with lung compartmentalized AV2S3+ T cells. At follow-up after recovery, reduced numbers of BAL fluid AV2S3+ T cells were found. Interestingly, BAL fluid of a healthy monozygotic twin sister contained normal numbers of AV2S3+ lung T cells. This report shows the T-cell repertoire of BAL fluid T cells to correlate with the disease (sarcoidosis). indicating a local and specific immune response triggered by an unknown antigen in sarcoidosis.

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Citations

Aug 9, 2007·Proceedings of the American Thoracic Society·Johan Grunewald, Anders Eklund
Dec 1, 2007·The Clinical Respiratory Journal·Johan Grunewald
Jan 24, 2015·Respiratory Medicine·Michiru SawahataMasashi Bando
Nov 1, 2006·Expert Review of Clinical Immunology·Johan GrunewaldJan Wahlström
Aug 13, 2002·Current Opinion in Pulmonary Medicine·Carlo AgostiniGianpietro Semenzato
Dec 14, 2011·Expert Review of Clinical Immunology·Johan Grunewald

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