Specific CD8+ T cell responses correlate with control of simian immunodeficiency virus replication in Mauritian cynomolgus macaques.

Journal of Virology
Melisa L BuddeDavid H O'Connor

Abstract

Specific major histocompatibility complex (MHC) class I alleles are associated with an increased frequency of spontaneous control of human and simian immunodeficiency viruses (HIV and SIV). The mechanism of control is thought to involve MHC class I-restricted CD8(+) T cells, but it is not clear whether particular CD8(+) T cell responses or a broad repertoire of epitope-specific CD8(+) T cell populations (termed T cell breadth) are principally responsible for mediating immunologic control. To test the hypothesis that heterozygous macaques control SIV replication as a function of superior T cell breadth, we infected MHC-homozygous and MHC-heterozygous cynomolgus macaques with the pathogenic virus SIVmac239. As measured by a gamma interferon enzyme-linked immunosorbent spot assay (IFN-γ ELISPOT) using blood, T cell breadth did not differ significantly between homozygotes and heterozygotes. Surprisingly, macaques that controlled SIV replication, regardless of their MHC zygosity, shared durable T cell responses against similar regions of Nef. While the limited genetic variability in these animals prevents us from making generalizations about the importance of Nef-specific T cell responses in controlling HIV, these results suggest th...Continue Reading

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Citations

Nov 1, 2013·ILAR Journal·Roger W WisemanDavid H O'Connor
Sep 12, 2013·PloS One·Emily AdlandPhilippa C Matthews
Apr 26, 2013·Current Opinion in HIV and AIDS·Joern E Schmitz, Birgit Korioth-Schmitz
Feb 10, 2016·Frontiers in Immunology·Benjamin B PolicicchioCristian Apetrei
Jun 2, 2015·Human Immunology·Catherine J WestbrookGustavo Palacios
Jul 28, 2017·Journal of Medical Primatology·Hongzhao LiMa Luo
Oct 23, 2015·Journal of Virology·Dane D GellerupShelby L O'Connor
Jan 17, 2020·Journal of Medical Virology·Jaclyn K MannThumbi Ndung'u
Aug 29, 2019·Cells·Takashi Shiina, Antoine Blancher

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