Specific central memory T cells in the bone marrow of patients immunized against tyrosinase peptides

Journal of Immunotherapy
Anne LetschCarmen Scheibenbogen

Abstract

The goal of vaccination against tumors is the induction of effector T cells mediating tumor destruction and memory T cells providing long-term immunity. Several previous studies in patients vaccinated with major histocompatibility complex (MHC) class I peptides failed to show induction of central memory T cells, which are considered important to provide long-term memory. This study examined the subset composition and function of specific T cells generated by immunization with MHC class I binding tyrosinase peptides in combination with the adjuvants granulocyte-macrophage colony-stimulating factor and keyhole limpet hemocyanin in peripheral blood (PB) and bone marrow (BM) of melanoma patients. Most of the tyrosinase-specific T cells in PB had a CD45RA(+)CCR7(-) effector phenotype. In contrast to this, a large subset of tyrosinase-specific T cells in BM were memory T cells, including CD45RA(+)CCR7(-) central and CD45RA(-)CCR7(-) effector memory T cells. BM tyrosinase-specific T cells were functional, because they produced interferon-gamma and had a high proliferative potential. This study suggests that peptide vaccination can generate a fully functional memory T-cell response characterized by central and effector memory phenotype...Continue Reading

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Citations

Sep 14, 2007·Journal of Peptide Science : an Official Publication of the European Peptide Society·Ali Azizi, Francisco Diaz-Mitoma
Oct 26, 2007·European Journal of Immunology·Anne LetschCarmen Scheibenbogen
Oct 10, 2009·International Journal of Cancer. Journal International Du Cancer·Sebastian OchsenreitherUlrich Keilholz
Oct 10, 2009·Journal of Immunotherapy·Il-Kang NaCarmen Scheibenbogen
Feb 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ali AziziFrancisco Diaz-Mitoma
Apr 13, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ulrich KeilholzCarmen Scheibenbogen
Mar 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yushe DangMary L Disis

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