PMID: 9659985Jul 11, 1998Paper

Specific changes in food intake elicited by blockade or activation of glutamate receptors in the nucleus accumbens shell

Behavioural Brain Research
T R StratfordA Kelley

Abstract

Blockade of non-N-methyl-D-aspartic acid (NMDA) ionotropic glutamate receptors in the nucleus accumbens shell (AcbSh) with 6,7-dinitroquinoxaline-2,3-dione (DNQX) elicits intense feeding in satiated rats. In order to determine whether or not this feeding is part of a general behavioral activation, we observed the effect of intra-AcbSh DNQX injections on intake of solid food, liquid food, and water, and on gnawing behavior. In addition, we investigated the possibility that activation of a subset of these receptors with (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) could suppress feeding. DNQX significantly increased intake of solid and liquid food, but did not significantly affect water intake or gnawing behavior. Furthermore, injections of AMPA into the AcbSh suppressed deprivation-induced feeding and intake of a palatable 5% sucrose solution without affecting water intake in water-deprived rats. Taken together, these data suggest that DNQX is acting on a system specifically involved with the regulation of food intake.

References

May 1, 1975·Journal of Comparative and Physiological Psychology·R J Waldbillig
Jan 1, 1990·Psychopharmacology·D Wirtshafter, J C Krebs
Nov 4, 1988·Science·G F Koob, F E Bloom
Jul 1, 1986·Pharmacology, Biochemistry, and Behavior·G D Carr, N M White
Dec 1, 1986·Pharmacology, Biochemistry, and Behavior·K R Evans, F J Vaccarino
Oct 1, 1985·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·P J BushnellE D Palmes
Jan 1, 1970·Psychological Review·E S ValensteinJ W Kakolewski
Mar 1, 1993·Pharmacology, Biochemistry, and Behavior·J D SalamoneS Rogers
Oct 1, 1995·Pharmacology, Biochemistry, and Behavior·D B Gilbert, S J Cooper
Apr 1, 1954·Journal of Comparative and Physiological Psychology·F D SHEFFIELD, B A CAMPBELL

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Citations

Sep 20, 2006·Psychopharmacology·Saleem M Nicola
Jan 17, 2007·Psychopharmacology·Karen K SzumlinskiM Scott Bowers
May 6, 2009·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Morteza ZendehdelJavad Cheraghi
Mar 14, 2000·Physiology & Behavior·B O WardP G Clifton
Sep 22, 2000·Peptides·C PolidoriM Massi
Oct 13, 2011·Behavioral Neuroscience·Matthew D PuhlPatricia S Grigson
Dec 13, 2012·Translational Psychiatry·A JeanV Compan
Dec 1, 2004·Neuroreport·Thomas R Stratford, David Wirtshafter
Jul 8, 2000·Epilepsia·R S Greenwood
Jul 23, 1999·Annals of the New York Academy of Sciences·A E Kelley
Apr 2, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael KrauseHoward L Fields
Jul 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Megan St PetersMartin Sarter
Jun 18, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Robert M SearsRalph J DiLeone
Dec 19, 2015·Glia·Jonathan-Julio Lorea-HernándezFernando Peña-Ortega
Sep 2, 2014·Journal of the Neurological Sciences·Dan WangXinjin Guo
Nov 25, 2004·The Journal of Comparative Neurology·Rodrigo A EspañaCraig W Berridge
Dec 22, 2015·Journal of Chemical Neuroanatomy·László Zoltán ReinitzVeronika Jancsik
Jan 15, 2016·Journal of Chemical Neuroanatomy·David J BarkerMarisela Morales
May 10, 2011·Physiology & Behavior·B G StanleyT Kee
Apr 13, 2011·Sleep Medicine Reviews·Jerome M Siegel
Feb 19, 2011·Neuroscience and Biobehavioral Reviews·Philip J RyanAndrew L Gundlach
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