PMID: 9417814Mar 7, 1998Paper

Specific changes in the pancreatic expression of the interleukin 1 family of genes during experimental acute pancreatitis

Cytokine
G W Fink, J G Norman

Abstract

Interleukin 1beta (IL-1beta) is produced in large amounts during acute pancreatitis and is believed to play a primary role in determining pancreatitis severity and the degree of pancreatic tissue destruction. This study was undertaken to characterize intrapancreatic production of IL-1beta and the remainder of the IL-1 family of genes during sterile acute pancreatitis. Moderate or severe necrotizing pancreatitis was induced by the intraperitoneal injection of a cholecystokinin analogue or the feeding of a choline deficient diet, respectively. Animals were killed during the progression of pancreatitis with severity scored by histological grading and serum amylase concentration. The expression of IL-1beta, IL-1 Receptor 1 (IL-1R1), Il-1R2, IL-1R antagonist (IL-1Ra), and ICE mRNA within the pancreas was examined by quantitative differential RT-PCR. Corresponding intrapancreatic and serum proteins were measured by enzyme-linked immunosorbent assay (ELISA). There was constitutive expression of pancreatic IL-1R1, IL-1R2, IL-1Ra, and ICE but not IL-1beta. As pancreatitis developed, mRNA for IL-1beta, IL-1Ra, and ICE increased in parallel with the degree of pancreatitis severity (all P<0.001 vs baseline) while mRNA for both receptors re...Continue Reading

Citations

Sep 2, 1999·The Surgical Clinics of North America·W Denham, J Norman
Oct 12, 2002·Journal of the American College of Surgeons·Richard T EthridgeB Mark Evers
Mar 27, 2007·Surgical Infections·Tercio De CamposRaul Coimbra
Dec 24, 2005·Shock·Jill Granger, Daniel Remick
Mar 15, 2012·Pancreas·Rafaz HoqueWajahat Z Mehal
Dec 17, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Joelle M-J RomacRodger A Liddle
Sep 7, 2007·Neuroimmunomodulation·Hyo-Jin AnJae-Young Um
Jul 5, 2005·Expert Opinion on Investigational Drugs·W Denham, J Norman
Oct 15, 2014·Journal of Veterinary Internal Medicine·J PaekM-P Yang
Apr 26, 2005·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Madhav BhatiaLakshmi Chevali
Jan 31, 2006·The American Journal of Medicine·Savio ReddymasuPaul A Jordan
Apr 7, 2015·International Immunopharmacology·Dong-Goo KimSung-Joo Park
May 22, 2016·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·Pankaj Singh, Pramod Kumar Garg
Oct 20, 2000·The Journal of Laboratory and Clinical Medicine·C D UlrichS Ward
Nov 18, 2006·The Journal of Surgical Research·Misho O SimovicSteven C Stain
Feb 5, 2000·The Journal of Pathology·M BhatiaJ Slavin
Oct 27, 2017·International Journal of Molecular Sciences·Yoo Kyung Jeong, Hyeyoung Kim
Feb 22, 2017·World Journal of Gastrointestinal Pharmacology and Therapeutics·Murli ManoharAnil Mishra
Oct 17, 2018·Canadian Journal of Physiology and Pharmacology·Hua-Li HuangHe-Ping Qin
Aug 30, 2014·World Journal of Gastroenterology : WJG·Kristin S InmanNicole R Murray
May 16, 2001·American Journal of Physiology. Gastrointestinal and Liver Physiology·E VaqueroS J Pandol
May 25, 2013·World Journal of Gastroenterology : WJG·Ibrahim AkyaziMukaddes Ozcan
Jan 5, 2002·Scandinavian Journal of Gastroenterology. Supplement·M J Bruno
Aug 23, 2005·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·M Bhatia

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