PMID: 11927664Apr 3, 2002Paper

Specific contribution of human T-type calcium channel isotypes (alpha(1G), alpha(1H) and alpha(1I)) to neuronal excitability

The Journal of Physiology
J CheminP Lory

Abstract

In several types of neurons, firing is an intrinsic property produced by specific classes of ion channels. Low-voltage-activated T-type calcium channels (T-channels), which activate with small membrane depolarizations, can generate burst firing and pacemaker activity. Here we have investigated the specific contribution to neuronal excitability of cloned human T-channel subunits. Using HEK-293 cells transiently transfected with the human alpha(1G) (Ca(V)3.1), alpha(1H) (Ca(V)3.2) and alpha(1I) (Ca(V)3.3) subunits, we describe significant differences among these isotypes in their biophysical properties, which are highlighted in action potential clamp studies. Firing activities occurring in cerebellar Purkinje neurons and in thalamocortical relay neurons used as voltage clamp waveforms revealed that alpha(1G) channels and, to a lesser extent, alpha(1H) channels produced large and transient currents, while currents related to alpha(1I) channels exhibited facilitation and produced a sustained calcium entry associated with the depolarizing after-potential interval. Using simulations of reticular and relay thalamic neuron activities, we show that alpha(1I) currents contributed to sustained electrical activities, while alpha(1G) and al...Continue Reading

References

Oct 1, 1992·Journal of Neurophysiology·J R Huguenard, D A McCormick
Oct 1, 1992·Journal of Neurophysiology·D A McCormick, J R Huguenard
Mar 1, 1990·Trends in Neurosciences·B W Connors, M J Gutnick
Jun 3, 1982·Nature·R Llinás, H Jahnsen
Oct 29, 1993·Science·M SteriadeT J Sejnowski
Oct 1, 1993·The Journal of Physiology·D ContrerasM Steriade
Jan 1, 1996·Annual Review of Physiology·J R Huguenard
Jan 1, 1997·Annual Review of Neuroscience·D A McCormick, T Bal
Aug 15, 1997·Neural Computation·M L Hines, N T Carnevale
Feb 4, 1999·Journal of Neurochemistry·M E WilliamsK A Stauderman
Mar 23, 1999·Pflügers Archiv : European journal of physiology·N KlugbauerF Hofmann
Jul 22, 1999·Annals of the New York Academy of Sciences·I M Raman, B P Bean
Aug 6, 1999·The Journal of General Physiology·J R SerranoS W Jones
Feb 29, 2000·The Journal of Biological Chemistry·A MonteilJ Nargeot
Apr 6, 2000·The Journal of Biological Chemistry·A MonteilJ Nargeot
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·P BijlengaL Bernheim
Nov 14, 2000·The Journal of Biological Chemistry·J E McRoryT P Snutch
Apr 24, 2001·Pflügers Archiv : European journal of physiology·S O ZhuravlevaY M Shuba

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Citations

Sep 18, 2013·Pflügers Archiv : European journal of physiology·Régis C LambertNathalie Leresche
Feb 26, 2004·Bioorganic & Medicinal Chemistry·Hilary A SchenckMilton L Brown
Sep 8, 2010·Brain Research·Oline K RønnekleivChunguang Zhang
Mar 1, 2006·Progress in Biophysics and Molecular Biology·Fabien BretteLaurent Sallé
Jan 13, 2005·British Journal of Pharmacology·Pavle M JoksovicSlobodan M Todorovic
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Fabrice MargerDenis Ardid
Nov 19, 2010·The Journal of Biological Chemistry·Yogananda S MarkandeyaRavi C Balijepalli
Jun 18, 2009·Assay and Drug Development Technologies·Francesco BelardettiTerrance P Snutch
Dec 11, 2003·Journal of Neurophysiology·Sherwin C LeeAndrew T Ishida
Apr 10, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·John D GraefDwayne W Godwin
Aug 28, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chunguang ZhangOline K Rønnekleiv
Apr 16, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jeanne T PazJohn R Huguenard
May 31, 2014·World Journal of Gastroenterology : WJG·Anita AnnaháziTibor Wittmann
Feb 13, 2014·Pflügers Archiv : European journal of physiology·Eunji Cheong, Hee-Sup Shin
Mar 1, 2014·Pflügers Archiv : European journal of physiology·Vincenzo CrunelliRégis C Lambert
Apr 8, 2014·Cell Calcium·Paula P PerissinottiErika S Piedras-Rentería
Nov 29, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ildar T BayazitovStanislav S Zakharenko
Oct 21, 2015·Proceedings of the National Academy of Sciences of the United States of America·Iulia BlesneacPhilippe Lory
Jul 3, 2013·Molecular Pain·Vinicius M GadottiGerald W Zamponi
Dec 10, 2015·Scientific Reports·Kyunghwa JeongWalton D Jones
Dec 9, 2010·Channels·Stuart M Cain, Terrance P Snutch
Apr 29, 2015·The Journal of General Physiology·Osama F HarrazDonald G Welsh
Jan 23, 2015·Frontiers in Cellular Neuroscience·Paula P PerissinottiErika S Piedras-Rentería
Sep 23, 2016·Channels·Nathalie Leresche, Régis C Lambert
Dec 17, 2008·Biochimica Et Biophysica Acta·Sylvaine HucPhilippe Lory
Aug 6, 2014·Neuroscience Research·Vinicius Nikolaos Samios, Takafumi Inoue
Mar 24, 2017·Neuron·Philippe Coulon, Carole E Landisman
Jul 26, 2017·Channels·Stuart M CainTerrance P Snutch

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