PMID: 9182876Jan 1, 1997Paper

Specific demethylation of the CD4 gene during CD4 T lymphocyte differentiation

Molecular Immunology
M M Tutt LandolfiJ R Parnes

Abstract

The expression of CD4 during T cell development is a highly regulated process. Numerous regulatory elements have been identified including a promoter, two distinct enhancers and a silencer. Here we report a methylation site in the first intron of the CD4 gene that is specifically demethylated in cells which have previously, or are currently expressing CD4. In addition, this site becomes progressively demethylated as T lymphocytes differentiate from double-negative to double-positive to CD4 single-positive thymocytes, and finally to CD4 single-positive peripheral T lymphocytes. This specific and progressive demethylation suggests that this site represents another potential control region for the regulation of CD4.

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Citations

Dec 22, 1998·The Journal of Experimental Medicine·S ChanD Mathis
Feb 28, 2002·The Journal of Infectious Diseases·Christopher B WilsonMercedes Pérez-Melgosa
Oct 16, 1999·The Journal of Laboratory and Clinical Medicine·B Richardson, R Yung
Dec 4, 2002·Nature Reviews. Immunology·Dimitris Kioussis, Wilfried Ellmeier
Jun 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Silke JennrichUta Syrbe
Aug 7, 2002·The Journal of Nutrition·Sabine Maier, Alexander Olek

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