PMID: 7082588Jun 1, 1982Paper

Specific desensitization of rabbit platelets by platelet-activating factor (PAF-acether) and derivatives

British Journal of Haematology
C L Keraly, J Benveniste

Abstract

PAF-acether is a 1-O-alkyl-2 acetyl-sn-glycerol-3-phosphorylcholine which triggers platelet aggregation independently from ADP release and thromboxane A2 formation. PAF-acether-aggregated rabbit platelets did not respond to a second challenge with the same agonist, but still aggregated to arachidonic acid. This desensitization to PAF-acether was a dose-dependent phenomenon. Specific cross-desensitization to PAF-acether was achieved using PAF-acether from four cellular origins, synthetic PAF-acether and its 2-propionyl analogue. Conversely, 2-lyso-PAF-acether and PAF-acether enantiomer were unable to induce specific desensitization. These results suggest that PAF-acether, whatever its origin, exhibits identical active molecular site, and that the presence and the stereospecific position of the 2-acetyl group are critical for the interaction of PAF-acether with platelets.

References

Jun 28, 1979·Nature·M ChignardJ Benveniste
Jul 1, 1970·British Journal of Haematology·N G ArdlieJ F Mustard
Nov 1, 1980·British Journal of Haematology·M ChignardJ Benveniste
Aug 1, 1981·Biochimie·M TenceJ Benveniste
Oct 22, 1963·Biochimica Et Biophysica Acta· VAN DEENENL, G H DE HAAS

Citations

Jan 1, 1985·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·D J LenihanT C Lee
Jul 1, 1995·Journal of Lipid Mediators and Cell Signalling·D S WoodardL M McManus
Feb 22, 1983·Biochimica Et Biophysica Acta·M TenceJ Benveniste
Jul 1, 1988·British Journal of Clinical Pharmacology·N M RobertsP J Barnes
Mar 1, 1983·British Journal of Haematology·C L KeralyJ Benveniste
Feb 1, 1989·British Journal of Pharmacology·M A MartinsB B Vargaftig
Nov 1, 1994·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C Brodie

Related Concepts

Dose-Response Relationship, Drug
Lysophosphatidylcholines
Platelet Activating Factor
Platelet Aggregation

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