Specific diagnosis and follow-up of HIV-1 group O infection: RES-O data

Médecine et maladies infectieuses
Agnès DepatureauxJ-C Plantier

Abstract

HIV-1 group O (HIV-O), mainly found in Cameroon, has a very high genetic diversity with consequences on the diagnosis and treatment of patients, requiring the development of specific tools. We present the currently available tools for the specific detection of HIV-O and its therapeutic monitoring, and the first RES-O data, a French network for the identification and monitoring of patients infected by HIV-O. The diagnosis of infection was confirmed by group-specific envelope serotyping. The viral load was assessed by a specific technique, LTR-O, developed in the laboratory and compared to the nonspecific kit RealTime HIV-1 (Abbott). The sequencing of antiretroviral target regions (Protease, Reverse Transcriptase (RT), Integrase and Gp41), was performed by specific primers. The analysis of resistance mutations was performed with the ANRS algorithm used for HIV-M. HIV-O infection was confirmed for 117 patients. Measuring viral load showed the two techniques were equivalent, but with a tendency to under-quantification for the Abbott technique greater than 1 log for 5% of samples. 70 to 100% of the studied strains had at least 10 mutations in the Protease, four 4 in the RT, and one in Gp41, resulting in a natural genotypic resistanc...Continue Reading

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Citations

Jul 8, 2008·Médecine sciences : M/S·Martine PeetersEric Delaporte
Jun 16, 2010·Antimicrobial Agents and Chemotherapy·Agnès DepatureauxJean-Christophe Plantier
Jul 5, 2013·Clinical Microbiology Reviews·Thomas MourezJean-Christophe Plantier
Aug 5, 2015·PLoS Pathogens·Marie LeozJean-Christophe Plantier
Dec 16, 2011·Journal of Clinical Microbiology·Marie GueudinJean-Christophe Plantier
Sep 29, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Marion MorgandFrancis Barin
Aug 25, 2012·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Agnès DepatureauxJean-Christophe Plantier
May 29, 2015·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Agnès DepatureauxMark A Wainberg

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