Specific docking of apolipoprotein A-I at the cell surface requires a functional ABCA1 transporter

The Journal of Biological Chemistry
Olivier ChambenoitGiovanna Chimini

Abstract

The identification of defects in ABCA1 as the molecular basis of Tangier disease has highlighted its crucial role in the loading with phospholipids and cholesterol of nascent apolipoprotein particles. Indeed the expression of ABCA1 affects apolipoprotein A-I (apoA-I)-mediated removal of lipids from cell membranes, and the possible role of ABCA1 as an apoA-I surface receptor has been recently suggested. In the present study, we have investigated the role of the ABCA1 transporter as an apoA-I receptor with the analysis of a panel of transfectants expressing functional or mutant forms of ABCA1. We provide experimental evidence that the forced expression of a functional ABCA1 transporter confers surface competence for apoA-I binding. This, however, appears to be dependent on ABCA1 function. Structurally intact but ATPase-deficient forms of the transporter fail to elicit a specific cell association of the ligand. In addition the diffusion parameters of membrane-associated apoA-I indicate an interaction with membrane lipids rather than proteins. These results do not support a direct molecular interaction between ABCA1 and apoA-I, but rather suggest that the ABCA1-induced modification of the lipid distribution in the membrane, evidenc...Continue Reading

References

May 1, 1994·Genomics·M F LucianiGiovanna Chimini
Mar 1, 1996·Biophysical Journal·M J Saxton
Jan 21, 1997·Biochimica Et Biophysica Acta·J BergeronYves L Marcel
Jun 24, 1998·Biochimica Et Biophysica Acta·Shinji Yokoyama
Apr 27, 1999·Biochimica Et Biophysica Acta·S W SakrGeorge H Rothblat
Jul 21, 1999·Proceedings of the National Academy of Sciences of the United States of America·J KorlachG W Feigenson
Aug 4, 1999·Nature Genetics·Angela R Brooks-WilsonMichael R Hayden
Aug 14, 1999·Biochimica Et Biophysica Acta·E M BeversR F Zwaal
Oct 19, 1999·The Journal of Clinical Investigation·R M LawnJohn F Oram
Jan 5, 2000·Proceedings of the National Academy of Sciences of the United States of America·P SchwilleW W Webb
Apr 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·J McNeishOmar L Francone
Jul 6, 2000·Current Opinion in Lipidology·John F Oram, A M Vaughan
Jul 14, 2000·The Journal of Biological Chemistry·Anna E BortnickOmar L Francone
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER

Citations

Nov 9, 2001·Biochemical and Biophysical Research Communications·G SzakácsBalázs Sarkadi
Feb 28, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Vassilis I ZannisMonty Krieger
Jun 20, 2007·European Biophysics Journal : EBJ·Stéphane OrlowskiXavier Collet
Jun 11, 2010·Molecular and Cellular Biochemistry·Alisha D HowardJose L Soulages
Dec 10, 2002·Biochemical and Biophysical Research Communications·Elda FavariLaura Calabresi
Apr 2, 2003·Trends in Cell Biology·Dan J Sillence, Frances M Platt
Nov 30, 2002·Trends in Cardiovascular Medicine·Didier Marguet, Giovanna Chimini
Apr 23, 2003·Molecular Genetics and Metabolism·Maxime DenisJacques Genest
Dec 4, 2001·Biochimica Et Biophysica Acta·C J Fielding, P E Fielding
Jan 18, 2003·Biochimica Et Biophysica Acta·Yannick HamonGiovanna Chimini
Feb 22, 2012·Cardiovascular Research·Sima AllahverdianGordon A Francis
Aug 2, 2002·Current Opinion in Lipidology·John F Oram
May 14, 2005·Current Opinion in Lipidology·Miranda Van EckTheo J C Van Berkel
Jun 5, 2002·Annual Review of Biochemistry·P Borst, R Oude Elferink
Nov 5, 2002·Annual Review of Medicine·Gerd Assmann, Jerzy-Roch Nofer
Sep 19, 2001·The Journal of Clinical Investigation·Albert K GroenF Kuipers
Jul 3, 2002·The Journal of Clinical Investigation·Roshni R SingarajaMichael R Hayden
Oct 9, 2002·The Journal of Clinical Investigation·A R TallN Wang
Dec 23, 2009·BMC Cell Biology·Ildikó KaszaLászló Homolya
Aug 22, 2007·PloS One·Patrick WilliamsonRobert A Schlegel
Sep 21, 2001·Biochemical and Biophysical Research Communications·K TsukamotoY Matsuzawa
Apr 12, 2008·Purinergic Signalling·Patrizia BalleriniFrancesco Caciagli
Oct 2, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Iris LorenziLucia Rohrer
Jun 11, 2004·Médecine sciences : M/S·Giovanna Chimini
Mar 5, 2004·Médecine sciences : M/S·Maria Carmen MartínezJean-Marie Freyssinet
Nov 1, 2003·Médecine sciences : M/S·Laurent O MartinezRonald Barbaras
Apr 24, 2010·FEBS Letters·Kohjiro NagaoKazumitsu Ueda
Nov 28, 2002·Annals of Medicine·Gerd Schmitz, Christa Buechler
Nov 15, 2011·Biochimica Et Biophysica Acta·Natalie FournierJean-Louis Paul
Jul 14, 2011·Biochimica Et Biophysica Acta·Kohjiro NagaoKazumitsu Ueda
Jul 27, 2011·Biochimica Et Biophysica Acta·Tomasz BocerGiovanna Chimini
Jul 27, 2010·Trends in Cardiovascular Medicine·Martin H KangMichael R Hayden
Jun 18, 2015·Journal of Neuropathology and Experimental Neurology·Yue YangThomas J Montine
Apr 7, 2009·Biochimica Et Biophysica Acta·Chongren Tang, John F Oram
Dec 19, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Masashi UedaShinichi Mashiba
May 11, 2011·The FEBS Journal·Kohjiro NagaoKazumitsu Ueda
Mar 8, 2005·Biochimica Et Biophysica Acta·Antje PohlAndreas Herrmann
Jul 11, 2006·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Giuseppe Danilo NorataAlberico Luigi Catapano
Jun 27, 2006·Biochimica Et Biophysica Acta·Clara CavelierArnold von Eckardstein
Apr 8, 2006·Chemistry and Physics of Lipids·Philippe F DevauxSusanne Bryde
Feb 24, 2006·Biochimica Et Biophysica Acta·Gregory BrubakerJonathan D Smith
Jan 31, 2006·Molecular and Biochemical Parasitology·Christopher D HustonJose E Teixeira
Nov 26, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xing LiuGuang-Hui Yi
Dec 4, 2012·Biochimie·Emmanuelle ReboulRobert S Molday
Jun 22, 2016·Advances in Chronic Kidney Disease·Shubha Ananthakrishnan, George A Kaysen
Oct 8, 2003·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yan Ru SuSergio Fazio
Jan 18, 2005·Journal of Lipid Research·M Alejandra TricerriH A Garda
Jan 3, 2004·Journal of Lipid Research·Jonathan D SmithMichael N Oda
Nov 28, 2002·Journal of Lipid Research·Veronique RigotGiovanna Chimini
Jan 20, 2004·Journal of Lipid Research·Kei-ichiro OkuhiraShinji Yokoyama
Oct 20, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jen-Hsiang T HsiaoWoojin Scott Kim
Jan 7, 2018·Journal of Lipid Research·Michael C Phillips
Jun 26, 2004·The Journal of Biological Chemistry·Stein RoosbeekMaryvonne Rosseneu
Jan 15, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Hailing LiaoYi Zhu
Nov 11, 2006·Circulation Research·John F Oram, Ashley M Vaughan
May 5, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Charulatha VedhachalamMichael C Phillips
Nov 12, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Srinivasa T ReddyAlan M Fogelman
Mar 5, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Patricia G YanceyGeorge H Rothblat
Mar 5, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·John F Oram
May 10, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·N Wang, A R Tall
Mar 9, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jikai LiuShuyi Si
Nov 14, 2013·The Journal of Biological Chemistry·Kailash GulshanJonathan D Smith
Apr 14, 2006·American Journal of Physiology. Cell Physiology·Shui-Pang TamRoger G Deeley
May 20, 2006·The Journal of Biological Chemistry·Doriane TrompierGiovanna Chimini
Jan 20, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ana ZarubicaGiovanna Chimini
Aug 28, 2002·The Journal of Biological Chemistry·Raymond H SeeMichael R Hayden
Dec 26, 2001·The Journal of Biological Chemistry·John M Dietschy, Stephen D Turley
Nov 15, 2017·Current Opinion in Lipidology·Jacques GenestHong Y Choi
Mar 15, 2002·The Journal of Biological Chemistry·Jonathan D SmithPing Zheng
May 12, 2001·The Journal of Biological Chemistry·E B NeufeldH Bryan Brewer
May 21, 2005·The Journal of Biological Chemistry·Nele Alder-BaerensAndreas Herrmann
Jan 22, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Katharina GausWendy Jessup
Jan 18, 2003·The Journal of Biological Chemistry·Genevieve EscherDmitri Sviridov
Jul 15, 2005·Vascular Medicine·S SoumianR G J Gibbs
Apr 20, 2001·The Journal of Biological Chemistry·N WangA R Tall
Mar 17, 2004·The Journal of Biological Chemistry·Hiroyuki SaitoMichael C Phillips
Jan 24, 2002·The Journal of Biological Chemistry·Kristin Gillotte-TaylorMichael C Phillips
May 2, 2009·Rejuvenation Research·Hicham Berrougui, Abdelouahed Khalil
Jul 11, 2020·Cellular & Molecular Biology Letters·Ambroise WuTomasz Trombik
Mar 19, 2003·Current Opinion in Lipidology·Yves L Marcel, Robert S Kiss
Sep 23, 2003·Current Opinion in Lipidology·Angel-Luis Garcia-Otin, Mario M Zakin
Nov 4, 2020·Annual Review of Physiology·Ashlee M PlummerMaofu Liao

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