Specific effect of the fragile-X mental retardation-1 gene (FMR1) on white matter microstructure

The British Journal of Psychiatry : the Journal of Mental Science
Tamar GreenAllan L Reiss

Abstract

Fragile-X syndrome (FXS) is a neurodevelopmental disorder associated with intellectual disability and neurobiological abnormalities including white matter microstructural differences. White matter differences have been found relative to neurotypical individuals. To examine whether FXS white matter differences are related specifically to FXS or more generally to the presence of intellectual disability. We used voxel-based and tract-based analytic approaches to compare individuals with FXS (n = 40) with gender- and IQ-matched controls (n = 30). Individuals with FXS had increased fractional anisotropy and decreased radial diffusivity values compared with IQ-matched controls in the inferior longitudinal, inferior fronto-occipital and uncinate fasciculi. The genetic variation associated with FXS affects white matter microstructure independently of overall IQ. White matter differences, found in FXS relative to IQ-matched controls, are distinct from reported differences relative to neurotypical controls. This underscores the need to consider cognitive ability differences when investigating white matter microstructure in neurodevelopmental disorders.

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Citations

Dec 8, 2015·Molecular and Cellular Neurosciences·Anita Bhattacharyya, Xinyu Zhao
Mar 25, 2016·Cerebral Cortex·Jennifer Lynn BrunoAllan L Reiss
Mar 5, 2016·NeuroImage. Clinical·Scott S HallAllan L Reiss
Dec 13, 2017·The European Journal of Neuroscience·Kevin J Mitchell
May 4, 2020·Journal of Neurodevelopmental Disorders·Khaleel A RazakCraig A Erickson
Dec 18, 2018·Psychiatry Research. Neuroimaging·Paul A RowleyJohn-Paul J Yu

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