PMID: 6978363Mar 26, 1982Paper

Specific elimination of the T lineage cells: effect of in vitro treatment with anti-Thy 1 serum without complement on the adoptive cell transfer system

Journal of Immunological Methods
K OnoéK Morikawa

Abstract

Thymocytes from C57BL/6(B6) mice treated with anti-Thy 1 antiserum without complement in vitro were transferred to lethally irradiated AKR mice. Five days following transfer, the proportion of Thy 1.2(+) cells recovered from the recipient spleen was significantly lower (7%) than that from the control mice which had received untreated cells (64%). the B6 spleen cells were treated in the same manner and transferred with SRBC (T-dependent antigen) or DNP-Ficoll (T-independent antigen) to irradiated syngeneic recipients. The recipients developed a response to SRBC which was significantly lower than that observed in control mice, but showed the same number of plaque-forming cell (PFC) against TNP-SRBC as the control group of mice which had received untreated B6 spleen cells. These results clearly show that in vitro pretreatment of lymphocytes with anti-Thy 1 serum without complement specifically resulted in elimination or inactivation of the T lineage cells in the host environment. The mechanisms of the elimination are discussed in this study.

References

Mar 1, 1978·The Journal of Experimental Medicine·R M ZinkernagelJ Klein
Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G FernandesR A Good
Nov 1, 1970·Transplantation·E A BoyseM E Lamm
Nov 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·M B Rittenberg, K L Pratt
Mar 1, 1969·Transplantation·D B AmosA Tiilikainen
Jan 1, 1980·The Journal of Experimental Medicine·K OnoéR A Good

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Citations

Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M NoguchiK Morikawa

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