PMID: 9548189Apr 21, 1998Paper

Specific expression of PP5/TFPI2 mRNA by syncytiotrophoblasts in human placenta as revealed by in situ hybridization

Placenta
K UdagawaK Miyazaki

Abstract

Placental protein 5 (PP5) is a placenta-derived glycoprotein with serine proteinase-inhibiting activity. To date its physiological functions have not been well elucidated. Recently, cDNA sequence analysis revealed that PP5 belongs to the Kunitz-type proteinase inhibitor family and it is identical to tissue factor pathway inhibitor-2 (TFPI-2), homologous to TFPI. Northern blot analysis demonstrated that placental tissue is extremely rich in the transcripts. This study localized PP5/TFPI-2 mRNA in placental tissues at three different gestational periods using in situ hybridization. PP5/TFPI-2 mRNA was specifically detected in syncytiotrophoblast at any gestational period examined, suggesting that syncytiotrophoblast is the principal production site of PP5/TFPI-2 in developing placental tissues. This mRNA expression pattern of PP5/TFPI-2 is quite different from that of TFPI, which is mainly found in vascular endothelial cells. The results indicated possible roles of PP5/TFPI-2 in the trophoblast differentiation and in the maintenance of intervillous blood flow. Also, Northern analysis demonstrated no or little expression of PP5/TFPI-2 in four choriocarcinoma cell lines, in contrast to its abundant expression in syncytiotrophoblast.

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Citations

Sep 25, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jarosław KuczyńskiMieczysław Uszyński
May 24, 2003·Best Practice & Research. Clinical Haematology·Naomi LanirBenjamin Brenner
Jun 8, 2011·Birth Defects Research. Part A, Clinical and Molecular Teratology·Jorge A Piedrahita
Apr 4, 2015·American Journal of Obstetrics and Gynecology·Offer ErezJecko Thachil
Jan 5, 2011·European Journal of Pharmacology·Jun-Jie PanJian Li
Dec 10, 2008·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Offer ErezJuan Pedro Kusanovic
Nov 18, 2008·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Offer ErezRoberto Romero
Nov 4, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Offer ErezSonia S Hassan
Dec 29, 2011·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Qiongjie ZhouXiaotian Li
Dec 2, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Lacramioara IvanciuCristina Lupu
Apr 28, 2006·The Journal of Biological Chemistry·Antoni X Torres-ColladoJuan C Rodríguez-Manzaneque
Sep 30, 2014·The Journal of Biological Chemistry·Kanagasabai VadivelS Paul Bajaj
Feb 28, 2019·Frontiers in Physiology·Loes A OosterhoffFrank G van Steenbeek

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