Specific expression of spinal Fos after PAR-2 stimulation in mast cell-depleted rats

Neuroreport
Atsufumi KawabataH Nishikawa

Abstract

Protease-activated receptor-2 (PAR-2) in the sensory neurons may be involved in nociceptive processing. We attempted to detect and characterize specific expression of spinal Fos, a marker of nociception, in mast cell-depleted rats. Intraplantar (i.pl.) administration of not only the PAR-2 agonist SLIGRL-NH2, but also the control peptide LSIGRL-NH2, induced Fos expression in naive rats, whereas only the former specifically produced Fos expression in mast cell-depleted rats. This Fos expression was blocked by intrathecal DAMGO, a mu-opioid agonist, and, in part, by i.pl. calphostin C, a protein kinase C (PKC) inhibitor. Thus, specific expression of spinal Fos following peripheral PAR-2 activation is detectable in mast cell-depleted rats, suggesting activation of spinal nociceptive neurons, which is partially mediated by activation of PKC.

References

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Citations

Jul 3, 2004·Neuroreport·Atsufumi KawabataAkiko Ogawa
Apr 18, 2008·Neuroreport·Tasuku NakanoYasushi Kuraishi
Jul 24, 2003·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Ryotaro Kuroda, Atsufumi Kawabata
Jul 2, 2003·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Atsufumi Kawabata
Jul 18, 2002·Japanese Journal of Pharmacology·Naoyuki KawaoAtsufumi Kawabata
Jan 26, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Ayumi SakamotoYasushi Kuraishi
Apr 17, 2007·Life Sciences·Hiroyasu IshikuraAtsufumi Kawabata
Mar 24, 2004·Journal of Pharmacological Sciences·Naoyuki KawaoAtsufumi Kawabata
Mar 27, 2004·Physiological Reviews·Valeria S Ossovskaya, Nigel W Bunnett
Nov 13, 2007·British Journal of Pharmacology·A KawabataF Sekiguchi
Mar 8, 2006·British Journal of Pharmacology·Atsufumi KawabataNaohiro Saito
Feb 21, 2004·The Journal of Pharmacology and Experimental Therapeutics·Atsufumi KawabataRobin Plevin
May 3, 2006·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Atsufumi Kawabata

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