Specific fluorometric assay for direct determination of amikacin by molecularly imprinting polymer on high fluorescent g-C3 N4 quantum dots

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Javad HassanzadehMehdi Rahimi-Nasrabadi

Abstract

Here, a specific and reliable fluorometric method for the rapid determination of amikacin was developed based on the molecularly imprinting polymer (MIP) capped g-C3N4 quantum dots (QDs). g-C3N4 QDs were obtained by facile and one-spot ethanol-thermal treatment of bulk g-C3N4 powder and showed a high yield fluorescence emission under UV irradiation. The MIP layer was also created on the surface on QDs, via usual self-assembly process of 3-aminopropyl triethoxysilane (APTES) functional monomers and tetraethyl ortho-silicate (TEOS) cross linker in the presence of amikacin as template molecules. The synthesized MIP-QDs composite showed an improved tendency toward the amikacin molecules. In this state, amikacin molecules located adjacent to the g-C3N4 QDs caused a remarkable quenching effect on the fluorescence emission intensity of QDs. This effect has a linear relationship with amikacin concentration and so, formed the basis of a selective assay to recognize amikacin. Under optimized experimental conditions, a linear calibration graph was obtained as the quenched emission and amikacin concentration, in the range of 3-400 ng mL-1 (4.4-585.1 nM) with a detection limit of 1.2 ng mL-1 (1.8 nM). The high selectivity of MIP sites as we...Continue Reading

Citations

Sep 5, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hongji LiuRongrong Nie
Nov 30, 2019·Chemical Communications : Chem Comm·Zesheng ZhuoYongqiang Dong
Aug 13, 2020·Critical Reviews in Analytical Chemistry·Adishri RautVasanti Suvarna
Oct 31, 2020·Environmental Science and Pollution Research International·Mojtaba RostamiAlireza Badiei
Jun 15, 2021·Chemistry, an Asian Journal·Jie-Ran ZhangYu Zhang
Jul 20, 2020·Current Drug Delivery·Mansureh AlizadehAbolfazl Bezaatpour
Dec 2, 2021·The Science of the Total Environment·Mohammad Mehdi Sabzehmeidani, Mahmood Kazemzad

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