PMID: 698820Oct 6, 1978Paper

Specific glycine uptake by identified neurons of Aplysia californica. II. Biochemistry

Brain Research
D J McAdooR A Novak

Abstract

Glycine is taken up twice as rapidly by neurons R3-R14 as by other identified neurons in the Aplysia parietovisceral ganglion. Earlier studies had shown that R3-R14 have much higher glycine concentrations than other Aplysia neurons. Most of the glycine taken up by R3-R14 was biochemically untransformed for at least 1 h following its uptake. Glycine is actively transported into into R3-R14 and other Aplysia neurons by carrier-mediated processes. Glycine uptake by R3-R14 was markedly reduced in the absence of Na+ and in the presence of Hg2+, while these treatments had little effect on glycine uptake by other Aplysia neurons. There appears to be a special glycine uptake system present in R3-R14 and a general glycine uptake system common to all Aplysia neurons. The elevated glycine concentrations and special glycine uptake associated with R3-R14 may indicate that glycine is utilized as a neurotransmitter by those neurons.

Citations

Sep 1, 1984·Cellular and Molecular Neurobiology·K E CarlsonE Aizenman
Oct 1, 1981·Journal of Neurocytology·J T HaskinsJ E Blankenship
Jan 1, 1984·Progress in Neurobiology·K S Rózsa
Jan 1, 1989·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·C Y LinD J McAdoo
Jun 20, 2007·Electrophoresis·Yun ChenEdgar A Arriaga
Nov 1, 1984·Journal of Neurochemistry·M W McCaman, J Stetzler
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Oct 15, 1980·The Journal of Comparative Neurology·Y C KongD M Lam
Jan 1, 1981·Infection·M F Michel, C C Priem
Jun 1, 1985·European Journal of Clinical Microbiology·E BouzaF Baquero
Sep 15, 1987·Experientia·J Koester, U T Koch
Dec 15, 1979·The Journal of Comparative Neurology·C H Price, D J McAdoo

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