PMID: 2503828Aug 1, 1989Paper

Specific HLA-DQB and HLA-DRB1 alleles confer susceptibility to pemphigus vulgaris

Proceedings of the National Academy of Sciences of the United States of America
S J ScharfH A Erlich

Abstract

The autoimmune dermatologic disease pemphigus vulgaris (PV) is associated with the serotypes HLA-DR4 and HLA-DRw6. Based on nucleotide sequence and oligonucleotide probe analysis of enzymatically amplified DNA encoding HLA-DR beta chain (HLA-DRB) and HLA-DQ beta chain (HLA-DQB; henceforth HLA is omitted from designations), we showed previously that the DR4 susceptibility was associated with the Dw10 DRB1 allele [encoding the mixed lymphocyte culture (MLC)-defined Dw10 specificity]. The DRw6 susceptibility similarly was shown to be associated with a rare DQB allele (DQB1.3), which differed from another nonsusceptible allele by only a valine-to-aspartic acid substitution at position 57. Given the linkage disequilibrium that characterizes HLA haplotypes, it is difficult to assign disease susceptibility to a specific locus rather than to a closely linked gene(s) on the same haplotype. To address this problem, we have analyzed all of the polymorphic loci of the class II HLA region (DRB1, DRB3, DQA, DQB, and DPB) on the DRw6 haplotypes in patients and controls. In 22 PV patients, 4 different DRw6 haplotypes were found that encode the same DQ beta chain (DQB1.3) but contained silent nucleotide differences at the DQB locus as well as c...Continue Reading

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Citations

Nov 1, 1989·Journal of Clinical Immunology·H A Erlich
Jan 1, 1990·Immunogenetics·G R McClureA B Begovich
Sep 10, 2008·Journal of Clinical Immunology·Sheida ShamsBehrouz Nikbin
Jan 1, 1992·Molecular Aspects of Medicine·M Baines, A Ebringer
Mar 16, 1991·Lancet·A V HillA J McMichael
Jun 1, 1991·Human Immunology·J MolkentinL A Baxter-Lowe
Jul 1, 1991·Human Immunology·J G BodmerT Sasazuki
Aug 1, 1991·Human Immunology·H NiizekiT Nishikawa
Sep 1, 1994·Human Immunology·J G BodmerT Sasazuki
Apr 1, 1989·Current Opinion in Immunology·G T Nepom
Jan 1, 2004·Human Immunology·Ephraim GazitRon Loewenthal
May 5, 2005·Journal of Autoimmunity·François TronMourad Ben Ayed
Sep 1, 1991·Baillière's Clinical Endocrinology and Metabolism·H A Erlich
Dec 1, 1991·Current Opinion in Immunology·M Ehrenstein, D Isenberg
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A B BegovichH A Erlich
Mar 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P SalgameB R Bloom
Mar 11, 1992·Nucleic Acids Research·Y M LoJ S Wainscoat
Mar 1, 1991·Tissue Antigens·J G BodmerT Sasazuki
Jul 1, 1992·Tissue Antigens·T S Fenske, L A Baxter-Lowe
Jan 1, 1991·Vox Sanguinis·J G BodmerT Sasazuki
Jan 1, 1994·Vox Sanguinis·J G BodmerT Sasazuki
Feb 1, 1991·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·H ErlichP S Walsh
Aug 1, 1991·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·J G BodmerT Sasazuki
Dec 1, 1994·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·J G BodmerT Sasazuki
May 20, 2009·Pharmacogenomics·Clive Bowman, Olivier Delrieu
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·E W PetersdorfJ A Hansen

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